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  1. The yellow fever vaccine produced at Fiocruz (previously Oswaldo Cruz Institute) is still the 17D attenuated strain, and the vaccine department proudly preserves the first vials of the vaccine from 1937. In 2021, this vaccine is manufactured at the ultra-modern glass-and-steel building of Bio-Manguinhos, but this is a relatively new development.

    • Ilana Löwy
    • 2021
  2. In the late 1930s, the 17D vaccine against yellow fever was produced in record time. 17D was and is an excellent vaccine. Its rapid diffusion led, however, to several problems, the most important among them being the 1942 massive contamination of the vaccine distributed to the US Army by the hepatitis B virus.

    • Ilana Löwy
    • 2021
  3. Abstract. After failed attempts at producing bacteria-based vaccines, the discovery of a viral agent causing yellow fever and its isolation in monkeys opened new avenues of research. Subsequent advances were the attenuation of the virus in mice and later in tissue culture; the creation of the seed lot system to avoid spontaneous mutations; the ...

    • Frierson Jg
    • 2010
  4. Sep 1, 2021 · The disease yellow fever (YF) is prevented by a live-attenuated vaccine, termed 17D, which has been in use since the 1930s. One dose of the vaccine is thought to give lifelong (35+ years) protective immunity, and neutralizing antibodies are the correlate of protection. Despite being a vaccine-preventable disease, YF remains a major public ...

    • Clairissa A Hansen, Alan D T Barrett
    • 10.3390/ph14090891
    • 2021
    • 2021/09
    • Yellow Fever Vaccine Recommendations
    • Contraindications
    • Precautions
    • Reactions to Yellow Fever Vaccine

    Yellow fever vaccine is recommended for people who are aged 9 months or older who are traveling to or living in areas at risk for yellow fever virus transmission in South America and Africa. Yellow fever vaccine may be required for entry into certain countries. Yellow fever vaccination requirements and recommendations for specific countries are ava...

    Allergy to a vaccine component
    Aged younger than 6 months
    Symptomatic HIV infection or CD4+ T-lymphocytes <200/mm3 (<15% of total in children aged <6 years)
    Thymus disorder associated with abnormal immune function
    Age 6 to 8 months
    Age 60 years or older
    Asymptomatic HIV infection and CD4+ T-lymphocytes 200 to 499/mm3 (15-24% of total in children younger than 6 years old)
    Pregnancy

    Reactions to yellow fever vaccine are generally mild and include headaches, myalgias, and low-grade pyrexia. There have been reports of rare but serious events following yellow fever vaccination. These events include anaphylaxis, yellow fever vaccine-associated viscerotropic disease (YEL-AVD), and yellow fever vaccine-associated neurologic disease ...

  5. The yellow fever vaccine is safe and affordable, providing effective immunity against yellow fever within 7-10 days for 95% of those vaccinated. A single dose of yellow fever vaccine is sufficient to confer sustained immunity and life-long protection against yellow fever disease and a booster dose of yellow fever vaccine is not needed.

  6. This report reviews the evidence related to main topics considered by the working group, including: 1. Need for booster doses every 10 years to maintain protection against yellow fever 2. Safety of the vaccine in selected special populations a. Persons aged 60 years and older b.