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  1. The yellow fever vaccine produced at Fiocruz (previously Oswaldo Cruz Institute) is still the 17D attenuated strain, and the vaccine department proudly preserves the first vials of the vaccine from 1937. In 2021, this vaccine is manufactured at the ultra-modern glass-and-steel building of Bio-Manguinhos, but this is a relatively new development.

    • Ilana Löwy
    • 2021
  2. Abstract. After failed attempts at producing bacteria-based vaccines, the discovery of a viral agent causing yellow fever and its isolation in monkeys opened new avenues of research. Subsequent advances were the attenuation of the virus in mice and later in tissue culture; the creation of the seed lot system to avoid spontaneous mutations; the ...

    • Frierson Jg
    • 2010
  3. Download (PPT) The 1951 Nobel Prize for medicine or physiology was awarded to South African physician and microbiologist Max Theiler for his discoveries concerning yellow fever and its treatment. His work not only resulted in the development of a vaccine against yellow fever but also showed how vaccines could be developed against other diseases.

    • Marc A. Shampo, Robert A. Kyle
    • 2003
  4. Sep 1, 2021 · The disease yellow fever (YF) is prevented by a live-attenuated vaccine, termed 17D, which has been in use since the 1930s. One dose of the vaccine is thought to give lifelong (35+ years) protective immunity, and neutralizing antibodies are the correlate of protection. Despite being a vaccine-preventable disease, YF remains a major public ...

    • Clairissa A Hansen, Alan D T Barrett
    • 10.3390/ph14090891
    • 2021
    • 2021/09
  5. use of yellow fever virus modified by in vitro cultivation for human immunization. J. Exp. Med. 65, 787–800 (1937) FURTHER READING Frierson, J. G. The yellow fever vaccine: a history. Yale J ...

  6. Aug 10, 2021 · The yellow fever vaccine is a single-dose vaccine that can provide lifelong protection for most people. It is a live-attenuated vaccine. This means that the vaccine uses a weakened, or attenuated ...

  7. Laboratory guidance. Yellow fever is an epidemic-prone vector-borne vaccine preventable viral disease that is transmitted to humans by the bites of infected mosquitos. In some of the unvaccinated individuals, the virus can cause severe illness including jaundice and bleeding (severe cases).

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