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  1. Abstract. After failed attempts at producing bacteria-based vaccines, the discovery of a viral agent causing yellow fever and its isolation in monkeys opened new avenues of research. Subsequent advances were the attenuation of the virus in mice and later in tissue culture; the creation of the seed lot system to avoid spontaneous mutations; the ...

    • Frierson Jg
    • 2010
  2. In the summer of 1693, a strange disease spread through Boston. Victims suffered from jaundice, high fever and black vomit. For more than two hundred years, yellow fever — as the disease became ...

    • American Experience
  3. The yellow fever vaccine produced at Fiocruz (previously Oswaldo Cruz Institute) is still the 17D attenuated strain, and the vaccine department proudly preserves the first vials of the vaccine from 1937. In 2021, this vaccine is manufactured at the ultra-modern glass-and-steel building of Bio-Manguinhos, but this is a relatively new development.

    • Ilana Löwy
    • 2021
  4. Sep 1, 2021 · The disease yellow fever (YF) is prevented by a live-attenuated vaccine, termed 17D, which has been in use since the 1930s. One dose of the vaccine is thought to give lifelong (35+ years) protective immunity, and neutralizing antibodies are the correlate of protection. Despite being a vaccine-preventable disease, YF remains a major public ...

    • Clairissa A Hansen, Alan D T Barrett
    • 10.3390/ph14090891
    • 2021
    • 2021/09
  5. Download (PPT) The 1951 Nobel Prize for medicine or physiology was awarded to South African physician and microbiologist Max Theiler for his discoveries concerning yellow fever and its treatment. His work not only resulted in the development of a vaccine against yellow fever but also showed how vaccines could be developed against other diseases.

    • Marc A. Shampo, Robert A. Kyle
    • 2003
  6. A single dose of yellow fever vaccine is sufficient to confer sustained immunity and life-long protection against yellow fever disease. A booster dose of the vaccine is not needed. The vaccine provides effective immunity within 10 days for 80-100% of people vaccinated, and within 30 days for more than 99% of people vaccinated.

  7. Yellow fever is a virus that causes hepatitis (inflammation of the liver) and hemorrhaging (severe bleeding problems). Symptoms include fever, chills, muscle pain, headache and jaundice (yellowing of the skin). Bleeding and severe liver damage caused by yellow fever virus kills 1 of every 5 people infected with the virus.