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  1. Sepsis in the severely immunocompromised patient The prevention and treatment of sepsis in the immunocompromised host present a challenging array of diagnostic and management issues. The neutropenic patient has a primary defect in innate immune responses and is susceptible to conventional and opportunistic pathogens.

    • Andre C. Kalil, Steven M. Opal
    • 2015
  2. A consequence of the need for this permanent immunosuppression is the high risk of opportunistic, community, and hospital-acquired infections, all of which can lead to sepsis. In addition, the detection of serious infections may be more challenging owing to patients' lower ability to mount the clinical symptoms that usually accompany sepsis.

    • Randy J McCreery, Diana F Florescu, Andre C Kalil
    • 2020
  3. The most common causes of pre-ICU immunosuppression are solid organ transplantation, hematopoietic stem cell transplantation, and infection due to human immunodeficiency virus. In this article, the authors review the most frequent infections that cause critical care illness in each of these 3 immunosuppressed patient populations. Keywords:

    • Diana F. Florescu, Uriel Sandkovsky, Andre C. Kalil
    • 2017
  4. May 17, 2016 · The lack of progress in sepsis diagnosis using biomarkers is partly related to the fact that we have concentrated on changes in single markers, whereas the sepsis response involves multiple players present at different times during the disease process. We are never going to find a single ideal marker for sepsis.

    • Jean Louis Vincent
    • 2016
  5. The only clues to diagnosing sepsis in such a patient might be reduced mental status, inability to tolerate dialysis because of hypotension, hypothermia, and glucose intolerance—there could be no obvious response to infection or predominant anti-inflammatory reaction.

    • Richard S Hotchkiss, Guillaume Monneret, Didier Payen
    • 2013
  6. “Sepsis is challenging because often the inciting event is a common infection. Patients often don’t think of common infections as potentially deadly ones.” While septic shock can be fatal, many patients can make a complete recovery if they are diagnosed and treated early with antibiotics, intravenous fluids, and blood pressure support.