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  1. www.ncbi.nlm.nih.gov › pmc › articlesThe Clinical Challenge of Sepsis Identification and Monitoring

    May 17, 2016 · An infection can be identified from clinical signs and microbiology findings, providing a diagnosis of sepsis if organ dysfunction is also present. CRP: C-reactive protein; PCT: procalcitonin. The onset of clinical signs and symptoms of a host response: Fever and chills are the most typical clinical reaction.

    • Table 1

      Sepsis Marker; Increases or stays high Low or decreasing; Is...

    • Figure

      Diagnosing sepsis from infection. An infection can be...

  2. pubmed.ncbi.nlm.nih.gov › 32691837Sepsis in Immunocompromised Patients Without Human ... - PubMed

    Jul 21, 2020 · This article provides an update on the current knowledge of sepsis in immunocompromised patients without human immunodeficiency virus. It reviews the most pertinent causes of sepsis in this population, and addresses the specific diagnostic and therapeutic challenges in neutropenia and solid organ and hematopoietic stem cell transplantation ...

    • Randy J McCreery, Diana F Florescu, Andre C Kalil
    • 2020

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  4. academic.oup.com › jid › articleSepsis in Immunocompromised Patients Without Human ...

    Jul 21, 2020 · More research is urgently needed to improve the diagnosis and prognosis of sepsis in immunocompromised patients, who frequently do not present with classic symptoms and signs of infection. More sensitive and specific microbial and host biomarkers will be necessary to further curb morbidity and mortality associated with sepsis.

    • Randy J McCreery, Diana F Florescu, Andre C Kalil
    • 2020

  5. www.ncbi.nlm.nih.gov › pmc › articlesDiagnostic Challenges in Sepsis - PMC - National Center for ...

    Oct 25, 2021 · In a prospective study of 1572 patients presenting to the Emergency Department, Ljungstrӧm et al. found neutrophil to lymphocyte count ratio to be superior to PCT and CRP for the diagnosis of bacterial sepsis (AUROC 0.68 vs 0.64 vs 0.57, p < 0.05) and the diagnosis of bacterial infection, although the difference in AUROC did not reach ...

    • Chris F. Duncan, Taryn Youngstein, Taryn Youngstein, Marianne D. Kirrane, Marianne D. Kirrane, Dagan...
    • 2021

  6. link.springer.com › article › 10Diagnostic Challenges in Sepsis | Current Infectious Disease ...

    Oct 25, 2021 · Purpose of Review Sepsis is a leading cause of death worldwide. Groundbreaking international collaborative efforts have culminated in the widely accepted surviving sepsis guidelines, with iterative improvements in management strategies and definitions providing important advances in care for patients. Key to the diagnosis of sepsis is identification of infection, and whilst the diagnostic ...

    • Chris F. Duncan, Taryn Youngstein, Taryn Youngstein, Marianne D. Kirrane, Marianne D. Kirrane, Dagan...
    • 2021

  7. journals.lww.com › jaapa › FulltextInfectious disease considerations in immunocompromised patients

    Overwhelming postsplenectomy infection (OPSI) refers to the development of fulminant sepsis in patients with asplenia, often due to encapsulated organisms causing meningitis or pneumonia. 6 A patient with OPSI can present with mild symptoms of infection, such as mild flu-like illness, and rapidly progress to fulminant sepsis and death. 6 ...

  8. pubmed.ncbi.nlm.nih.gov › 25939918Sepsis in the severely immunocompromised patient - PubMed

    The prevention and treatment of sepsis in the immunocompromised host present a challenging array of diagnostic and management issues. The neutropenic patient has a primary defect in innate immune responses and is susceptible to conventional and opportunistic pathogens. The solid organ transplant patient has a primary defect in adaptive immunity ...