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Jul 1, 2011 · Invasive fungal infections are infections of importance and are increasing in incidence in immunocompromised hosts such as patients who have had hematopoietic stem cell and solid organ transplants. Despite our expanded antifungal armamentarium, these infections cause considerable morbidity and mortality. Indeed, certain trends have emerged in ...
The major challenge, which none of the sepsis definitions address, is the difficulty in determining whether or not patients are infected, particularly in the early stages of presentation. Blood cultures can take 24–48 hours to turn positive, and most patients with sepsis do not have documented bacteremia.
Overwhelming postsplenectomy infection (OPSI) refers to the development of fulminant sepsis in patients with asplenia, often due to encapsulated organisms causing meningitis or pneumonia. 6 A patient with OPSI can present with mild symptoms of infection, such as mild flu-like illness, and rapidly progress to fulminant sepsis and death. 6 ...
Introduction. Older adults are at an increased risk of contracting infectious pathogens due to their declining immune system, in addition to other age-related changes throughout all body systems 1. Due to these vulnerabilities, older adults are at an increased risk of sepsis 1. Often, diagnosis and initiation of sepsis bundles are delayed due ...
eates the patient group at greatest risk for infection and sepsis [14]. 4. Neutropenic patients often lack the cardinal signs of in-flammation making an early diagnosis of infection and sepsis a major challenge [15]. 5. Despite the myriad of possible causes and explanations for fever in neutropenic patients, unexplained fever is in-
The immune suppressed state can modify the cardinal signs of inflammation, making accurate and rapid diagnosis of infection and sepsis difficult. Empiric antimicrobial agents can be lifesaving in these patients, but managing therapy in an era of progressive antibiotic resistance has become a real issue.
Nov 1, 2022 · Early diagnosis of IA in immunocompromised patients plays an important role in the patient’s outcome . Yet, it is difficult because the result of blood culture may be rarely positive, the clinical signs and symptoms of IA are nonspecific, and isolation of etiologic agents from non-sterile samples like sputum may be due to colonization.
