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  1. What is Zepbound? Zepbound is an injectable prescription medicine that may help adults with obesity, or with excess weight (overweight) who also have weight-related medical problems, lose weight and keep it off. Zepbound should be used with a reduced-calorie diet and increased physical activity.

    • What is Zepbound?
    • How much weight is lost on Zepbound?
    • Related/similar drugs
    • What is the difference between Mounjaro and Zepbound?
    • Common Zepbound side effects
    • Serious Zepbound side effects
    • Before using this medicine
    • Pregnancy
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    Zepbound (tirzepatide) is a GIP and GLP-1 receptor agonist used for weight loss for adults with obesity or who are overweight and have weight-related medical problems. Zepbound helps you to lose weight and maintain the weight loss and should be combined with diet and exercise. Zepbound works for weight loss by decreasing your appetite and slowing the movement of food from the stomach into the small intestine, which may make you feel full more quickly and for a longer period of time. 

    Zepbound is a once-weekly injection given under the skin (subcutaneous) using a pre-filled single-dose pen.

    Zepbound contains the same active ingredient (tirzepatide) as Mounjaro, and they are both made by Eli Lilly and Company. Zepbound is a GIP and GLP-1 receptor agonist, so its mechanism of action is it activates both GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) hormone receptors. 

    Zepbound received FDA approval on November 8, 2023, for chronic weight management in adults with obesity (with a BMI of 30 kg/m2 or greater) or adults who are overweight (with a BMI of 27 kg/m2 or greater) and also have weight-related medical problems such as hypertension, dyslipidemia, type 2 diabetes mellitus, obstructive sleep apnea or cardiovascular disease. Zepbound should be used together with diet and increased physical activity.

    Patients on Zepbound (tirzepatide) 5mg weekly lost 16.1 kg (35.5 lb) on average after 72 weeks. For Zepbound 10mg weekly dose, the average weight loss was 22.2 kg (48.9 lb), and for Zepbound 15mg weekly dose average weight loss was 23.6 kg (52.0 lb) over 72 weeks. Patients who used a placebo lost 2.4 kg (5.3 lb) over the 72 weeks. These results are...

    Mounjaro, semaglutide, phentermine, Wegovy, Saxenda, Alli

    Mounjaro and Zepbound are FDA-approved to treat different conditions, Mounjaro is FDA-approved for type 2 diabetes, and Zepbound is FDA-approved to help achieve and maintain weight loss.  Mounjaro and Zepbound both contain the same active ingredient, tirzepatide, and are made by Eli Lilly and Company. They are both given as weekly injections under ...

    The most common Zepbound side effects include abdominal pain, burping, constipation, diarrhea, dyspepsia, fatigue, gastroesophageal reflux disease, hair loss, hypersensitivity reactions, injection site reactions, nausea, and vomiting which affects 5% or more patients.

    Stop using this medicine and get emergency medical help if you have:

    •signs of an allergic reaction: hives; difficulty breathing; feeling light-headed; swelling of your face, lips, tongue, or throat; or

    •pancreatitis with symptoms of severe pain in your upper stomach spreading to your back, nausea and vomiting.

    Call your doctor at once if you have:

    •severe stomach problems;

    •eye side effects or vision changes, including blurry vision or blurred vision;

    You should not use Zepbound if you:

    •are allergic to the tirzepatide or any ingredients contained in this medicine; see ingredients at the bottom of this page.

    •have a personal or family history of medullary thyroid carcinoma (a type of thyroid cancer); or

    •multiple endocrine neoplasia type 2 (tumors in your glands).

    Tell your doctor if you have ever had:

    •pancreas problems;

    Tell your healthcare provider if you are pregnant, you become pregnant, or plan to become pregnant while using this medicine. It is not known if this medicine will harm your unborn baby. 

    Tell your doctor if you become pregnant while taking this medicine. There will be a pregnancy exposure registry for women who have taken Zepbound during pregnancy. The purpose of this registry is to collect information about the health of you and your baby. Talk to your healthcare provider about how you can take part in this registry or you may contact Eli Lilly and Company at 1-800-LillyRx (1-800-545-5979).

    Zepbound is a once-weekly injection for adults with obesity or overweight and weight-related medical problems. It works by decreasing appetite and slowing stomach emptying, and may cause side effects such as nausea, vomiting, and thyroid tumors.

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  2. Dec 1, 2023 · Zepbound is a liquid solution that you inject under your skin once per week. It helps you lose weight by reducing your appetite and slowing down digestion. Learn about its uses, side effects, dosage, cost, and more.

  3. Nov 8, 2023 · Zepbound is the second drug in a new class of obesity medications to be approved for weight loss, following Wegovy. And it is now likely the most effective treatment to combat obesity besides...

    • Dani Blum
  4. Nov 9, 2023 · Zepbound is a medication that uses tirzepatide, an active ingredient from the type 2 diabetes drug Mounjaro, to help adults with obesity lose weight and manage their blood sugar. It is an injection that is self-administered once a week and has a high success rate in clinical trials. Learn how it works, how much it costs, and what to expect from its side effects.

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