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Steve Carell

Gru/Dru

Kristen Wiig

Lucy

Trey Parker

Balthazar Bratt

Miranda Cosgrove

Margo

Russell Brand

Dr. Nefario

Dana Gaier

Edith

Nev Scharrel

Agnes

Pierre Coffin

Minions/Museum Director

Steve Coogan

Fritz/Silas Ramsbottom

Julie Andrews

Gru's Mom

Jenny Slate

Valerie Da Vinci

Michael Beattie (actor)

TV Show Host/Scar-Faced Man