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- Season 5 overviewSep 23, 2009-May 26, 201023 episodesSeason 5 episodes1. Nameless, Faceless Sep 23, 2009
- The team profiles a killer targeting an emergency room doctor; Hotch goes missing.
- 2. Haunted Sep 30, 2009
- The team searches for a disturbed man after he kills several people at a pharmacy.
- 3. Reckoner Oct 7, 2009
- A case in Rossi's hometown involves both his personal and professional lives.
- 4. Hopeless Oct 14, 2009
- BAU goes on a manhunt for a group of suspects who kill for the thrill of it.
- 5. Cradle to Grave Oct 21, 2009
- The team hunts a suspect who impregnates young women, has them give birth and murders them.
- 6. The Eyes Have It Nov 4, 2009
- The team tracks a serial killer who keeps his victims' eyes as souvenirs.
- 7. The Performer Nov 11, 2009
- The team investigates when a trail of murders seems to align with a rock star's tour schedule.
- 8. Outfoxed Nov 18, 2009
- After several families are murdered, the team seeks advice from one of the worst perpetrators.
- 9. 100 Nov 25, 2009
- The team races to help Hotchner find the Reaper and save his family.
- 10. Slave of Duty Dec 9, 2009
- When Hotchner takes a leave of absence from the BAU, the team must regroup to solve a home invasion.
- 11. Retaliation Dec 16, 2009
- The BAU must profile a criminal after he escapes from custody and begins a killing spree.
- 12. The Uncanny Valley Jan 13, 2010
- The team profiles a suspect who abducts women to fulfill a personal obsession.
- 13. Risky Business Jan 20, 2010
- The team investigates a series of teen suicides in a small Wyoming town.
- 14. Parasite Feb 3, 2010
- The team follows a con artist whose crimes escalate as his mental health declines.
- 15. Public Enemy Feb 10, 2010
- A serial killer targets random victims in highly visible places to create public fear.
- 16. Mosley Lane Mar 3, 2010
- The team profiles a child abductor who may have been keeping children for more than eight years.
- 17. Solitary Man Mar 10, 2010
- In order to catch a truck driver who is kidnapping women, the team must figure out his motive.
- 18. The Fight Apr 7, 2010
- Hotch and the team investigate the murder of several homeless men in San Francisco.
- 19. A Rite of Passage Apr 14, 2010
- The team heads to Texas to track a serial killer targeting illegal immigrants.
- 20. ... A Thousand Words May 5, 2010
- The team must profile a serial killer, covered in tattoos, who commits suicide.
- 21. Exit Wounds May 12, 2010
- Garcia travels to Alaska to investigate several murders.
- 22. The Internet Is Forever May 19, 2010
- The team profiles a killer who uses social networking websites to find victims.
- 23. Our Darkest Hour May 26, 2010
- The team tracks a serial killer in Los Angeles who targets families.