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Antonia Mattia is known for Late World with Zach (2002), Marriage Boot Camp: Reality Stars (2014) and Gene Simmons: Family Jewels (2006).
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Dr. Antonia Mattia has served as the Director of the Division of Biotechnology and GRAS Notice Review in the Office of Food Additive Safety, Center for Food Safety and Applied Nutrition at the US Food and Drug Administration since 2001.
- Introduction
- Definition of Food Additive
- The Gras Provision
- Gras Reviews and The Select Committee on Gras Substances
- The Gras Affirmation Petition Process
- The Gras Notification Program
- The Gras Regulation on Caffeine
- Regulatory History of Caffeine
- Caffeine Labeling
- Major Sources of Caffeine in Today's Marketplace
In August 2013, the National Institutes of Health held a workshop entitled “The Use and Biology of Energy Drinks: Current Knowledge and Critical Gaps” at the Neuroscience Center Building in Rockville, Maryland. The US Food and Drug Administration (FDA) participated by giving a presentation on the regulatory status of caffeine, a key component in en...
In 1958, in response to public concern about the increased use of chemicals in foods and food processing and with the support of the food industry, the US Congress enacted the Food Additives Amendment of 1958 (the 1958 amendment) to the Federal Food, Drug, and Cosmetic Act. The 1958 amendment requires that, before a new additive can be used in food...
Section 201(s) of the Federal Food, Drug and Cosmetic Act (codified in U.S Code Title 21 section 321) excludes from the definition of food additive any substance the intended use of which is generally recognized, among experts qualified by scientific training and experience to evaluate its safety (qualified experts), to be safe under the conditions...
On October 30, 1969, largely as a result of a recommendation in the report of the 1969 White House Conference on Food, Nutrition, and Health, President Richard M. Nixon, in his consumer message to Congress, directed the FDA to conduct a critical reevaluation of the safety of GRAS food substances. The GRAS review became a major project at the FDA's ...
In 1976, the FDA promulgated regulations to establish the procedures it would use, on its own initiative, to affirm the GRAS status of substances that were the subject of the SCOGS reviews.12 The affirmed uses of these substances are listed in Parts 184 and 186 of Title 21 of the CFR.8,9 The SCOGS reviews did not cover all GRAS substances (e.g., th...
In an effort to establish a workable, streamlined, predictable, transparent process that would encourage industry to voluntarily submit GRAS determinations to the FDA, a rule to replace the GRAS affirmation petition process with a notification procedure was proposed in 1997.15 This proposed rule replaced one voluntary process (petitions) with anoth...
Caffeine is listed as GRAS for use in cola-type beverages at levels not to exceed 200 parts per million (ppm) (0.02%).18This maximum level of use is equivalent to approximately 71 mg of caffeine in a 12-oz serving of cola, although colas typically contain roughly half this amount. The GRAS regulation for caffeine provides an affirmative statement t...
The regulatory history of caffeine is complex and is not typical of most food ingredients. Caffeine is one of the substances included on the original GRAS list following enactment of the Food Additives Amendment of 1958 (see the final rule19). As noted above, the FDA listed caffeine as GRAS when used in cola-type beverages at a level not to exceed ...
Under US law and regulations, neither caffeine nor caffeine-containing ingredients (e.g., coffee- and tea-derived flavoring ingredients) have special regulatory status with regard to labeling on food products or dietary supplements. Under the Code of Federal Regulations, all ingredients, including caffeine, in a retail food product must be listed b...
Caffeine occurs naturally in certain foods such as coffee, tea, and cocoa. Caffeine is also added directly or indirectly to some beverages, such as caffeine-containing energy drinks and soda-type beverages, as well as to some nonbeverage foods. The amount of caffeine in a food product varies, depending on multiple factors that include serving size,...
- Leah S Rosenfeld, Jeremy J Mihalov, Susan J Carlson, Antonia Mattia
- 2014
Feb 1, 2008 · Antonia Mattia, Robert Merker, Regulation of Probiotic Substances as Ingredients in Foods: Premarket Approval or “Generally Recognized as Safe” Notification, Clinical Infectious Diseases, Volume 46, Issue Supplement_2, February 2008, Pages S115–S118, https://doi.org/10.1086/523329
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