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  1. Jul 12, 2023 · To make personalized cancer vaccines, drug developers choose to include neoantigens on the basis of their expression levels in tumour biopsies and their predicted binding affinity to HLA...

  2. Aug 16, 2023 · Earlier this year, BioNTech published positive, but very preliminary, results of a personalized neoantigen mRNA vaccine for pancreatic cancer, a tumor type that until now had proven...

  3. Concept: Individualized mRNA cancer vaccine encoding for an individually selected number of patient-specific tumor neoantigens aiming to induce a potent and precise immune response against the patient’s unique tumor. mRNA Format: Optimized uridine mRNA (uRNA) for improved vaccine efficacy

  4. 4 days ago · In a small study 2 of the BioNTech–Genentech vaccine for treating pancreatic tumours, for example, only half of the trial participants developed T cells that were directed against any of the ...

  5. Jun 5, 2022 · By analyzing each patient’s tumor, BioNTech is able to identify the cancer mutations that may act as neoantigens. Each individual cancer vaccine encodes for neoantigen candidates with the highest likelihood to help the immune system to recognize the cancer.

  6. Jan 20, 2022 · It takes 1 to 2 months to produce a personalized mRNA cancer vaccine after tissue samples have been collected from a patient. “Speed is especially important for individualized cancer vaccination,” said Mathias Vormehr, Ph.D., codirector of Cancer Vaccines at BioNTech.

  7. May 30, 2024 · BBC. Elliot Pfebve is taking part in the trial. Thousands of NHS cancer patients in England are expected to get access to trials of a new type of treatment using vaccines to fight their disease ...

  8. Oct 20, 2023 · BioNTech has treated the first subject in a Phase II clinical trial of cancer vaccine candidate, autogene cevumeran (BNT122, RO7198457) to treat resected pancreatic ductal adenocarcinoma (PDAC), a type of solid tumour.

  9. Dec 5, 2023 · Recent clinical trials in melanoma and pancreatic cancer have shown the potential utility of personalized mRNA vaccines in reducing the risk of metastatic relapse after surgery.

  10. Apr 7, 2024 · An experimental approach to treating pancreatic cancer with the messenger RNA (mRNA)-based therapeutic cancer vaccine candidate autogene cevumeran continues to show potential to stimulate an immune response that may reduce the risk of the disease returning after surgery.

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