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    • kathy.katella-cofrancesco@yale.edu
    • How does Paxlovid work? Paxlovid is an antiviral therapy that consists of two separate medications packaged together. When you take your three-pill dose, two of those pills will be nirmatrelvir, which inhibits a key enzyme that the COVID virus requires in order to make functional virus particles.
    • When should I take Paxlovid? You have to take Paxlovid within five days of developing symptoms. Like all antivirals, Paxlovid works best early in the course of an illness—in this case, within the first five days of symptom onset, says Jeffrey Topal, MD, a Yale Medicine infectious diseases specialist who is involved in determining COVID-19 treatment protocols for Yale New Haven Hospital patients.
    • How often do I take Paxlovid? The standard dose is three Paxlovid pills twice daily for five days for a full course that adds up to 30 pills. It helps that the pills are packaged in a “dose card,” basically a medication blister pack that allows you to punch out the pills as needed.
    • Is Paxlovid similar to Tamiflu? “I think it's a good comparison,” says Dr. Roberts. Tamiflu is an antiviral drug that reduces flu symptoms. Both are prescription-only oral antiviral pills given early in illness.
  1. Aug 9, 2022 · How Does Paxlovid Work? Developed by global pharmaceutical giant Pfizer, Paxlovid is a combination therapy, which means it contains two different drugs: nirmatrelvir and ritonavir.

  2. Jul 5, 2023 · Paxlovid (nirmatrelvir/ritonavir) is a prescribed, orally administered (taken by mouth) antiviral medication used to treat symptoms of COVID-19, a viral respiratory illness caused by the SARS-CoV-2 virus. It is a brand-name medication that combines two antiviral drugs: nirmatrelvir and ritonavir.

  3. Jan 11, 2024 · How does Paxlovid work? And how effective is it? Paxlovid consists of two medications, which, when taken together, stop the virus from replicating in your body. A...

    • Dani Blum
    • How Does Paxlovid Work Against Covid-19?
    • How Long Does It Take For Paxlovid to Kick in?
    • How to Get A Paxlovid Prescription
    • Who Is Eligible to Receive Paxlovid?
    • Potential Paxlovid Side Effect: Metallic Taste in Mouth
    • 'Rebound' and Paxlovid
    • Drugs That Interact with Paxlovid
    • Who Shouldn't Take Paxlovid?
    • Does Paxlovid Prevent Long Covid?
    • Does Paxlovid Make You Less Contagious?

    Like other antivirals, Paxlovid is designed to stop a virus from making copies of itself. Limiting the number of copies helps the immune system fight off the virus. Made by Pfizer, Paxlovid is a combination of two drugs: ritonavir and nirmatrelvir. Nirmatrelvir, an oval, pink pill, is a so-called protease inhibitor – the same type of drug that turn...

    Paxlovid is given in a five-day course with three pills taken twice a day. Most people report feeling better by the second or third day on the drug. Pfizer only studied the medication for the full five days, so people should take them as prescribed, said Dr. Aida Habtezion, Pfizer's chief medical officer.

    Paxlovid is given only by prescription and can be administered by physicians, pharmacists, advanced practice registered nurses, and physician assistants who are licensed or authorized under state law to prescribe antivirals. The medication is available at pharmacies nationwide, and the government sponsors a "test-to-treat" program in various locati...

    Anyone aged 12 and older, has symptoms and is at high risk for severe disease is eligible to receive a free course of the medication, funded by the government. Because so many common conditions, such as obesity, put people at risk for severe disease and because everyone over 50 is eligible regardless of health status, the majority of adults qualify...

    Paxlovid's primary side effect is a metallic taste in the mouth during the five days of treatment. It goes away at the end. "The side effect profile, other than the taste, is extremely tolerable," Ely said. "Most people will have no side effects from that drug."

    One side effect commonly attributed to Paxlovid is "rebound" — testing positive for COVID-19 or symptoms showing up again two to eight days after recovery, typically lasting about three days. Both President Joe Biden and first lady Jill Bidenhad rebound symptoms after taking Paxlovid for their COVID-19 infections, as did infectious disease expert D...

    Paxlovid can interact with other drugs, including common ones like blood thinners, some cancer drugs, anticonvulsants, sedatives, erectile dysfunction medications, the herbal remedy St. John's Wort, and HIV medications. (A complete list of those drugs starts on page 11 of this fact sheet.) For people taking these medications, it is generally OK, wi...

    The medication should not be taken by people with severe liver or kidney disease or those who are allergic to either nirmatrelvir or ritonavir, according to the Food and Drug Administration authorization.

    The data is not conclusive on whether the medication can prevent the miserable symptoms that can linger for months or longer after a bout of COVID-19. But one recent study of veterans, not yet peer reviewed,showed that taking Paxlovid was associated with a reduced risk of symptoms such as blood clots, heart rhythm problems, fatigue, liver and kidne...

    Again, there's not enough data to say that Paxlovid makes people shed less virus. But generally, people who are sicker shed more virus, so reducing the severity of illness should cut down on shedding and therefore make people less contagious. Pfizer's data also shows that someone's viral load falls quickly once they start taking Paxlovid, Habtezion...

  4. May 9, 2024 · Paxlovid is a prescription medicine made up of two antiviral medications: nirmatrelvir with ritonavir. It works to stop the COVID-19 virus from multiplying, and reduces the amount of it in your body. Paxlovid pills are taken twice a day for five days.

  5. Paxlovid (ritonavir-boosted nirmatrelvir) is a preferred oral antiviral authorized for the treatment of mild-moderate COVID-19 illness. • Patients take a combination of pills twice a day for 5 days.

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