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1. • • The PCOH starting material can be purchased or prepared by reaction of phenyllithium or phenyl grignard with cyclohexanone. This alcohol is then be transformed into the amine by reaction with sodium azide (~90% yield) followed by reduction.
     chemistry.mdma.ch › hiveboard › rhodium

     Use of PCA (1-phenylcyclohexylamine) as a precursor

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   What was the first arylcyclohexamine?

   • The first arylcyclohexamine to be described was 1- (1-phenylcyclohexyl) amine, in 1907, almost 50 years before the synthesis of PCP [ 1 ]. Other analogues reported in the early 1950s included N -ethyl-1-phenylcyclohexylamine (PCE) and 1- (1-phenylcyclohexyl)morpholine (PCMo).

   Arylcyclohexamines (Ketamine, Phencyclidine, and Analogues)

   link.springer.com/referenceworkentry/10.1007/978-3-319-20790-2_124-1

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   Do phenylcycloalkylamine analogs possess double digit nanomolar range IC 50 values?

   • In the current study, we screened new P 1 ′ position 1-phenylcycloalkylamine analogs to find non-acidic inhibitors that possess double-digit nanomolar range IC 50 values. An extensive structure–activity relationship study was performed with various amine derivatives at the P 1 ′ position.

   Structure-guided design and synthesis of P1′ position 1

   www.sciencedirect.com/science/article/pii/S0968089611005402

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   Are there any arylcyclohexamine analogues?

   • The only case series of other arylcyclohexamine analogues comes from the Swedish STRIDA project, which reported 59 cases of acute 3- and 4-MeO-PCP toxicity [ 101 ]; 86.4 % were male and the median age was 26 years.

   Arylcyclohexamines (Ketamine, Phencyclidine, and Analogues)

   link.springer.com/referenceworkentry/10.1007/978-3-319-20790-2_124-1

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   Does chronic use of arylcyclohexamines affect working memory?

   • The subsequent reduction in dopaminergic activity seen with chronic use of arylcyclohexamines also plays a role in decreased working memory function of the prefrontal cortex [ 226 ].

   Arylcyclohexamines (Ketamine, Phencyclidine, and Analogues)

   link.springer.com/referenceworkentry/10.1007/978-3-319-20790-2_124-1

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3. pubchem.ncbi.nlm.nih.gov › 1-phenylcyclohexylamine1-Phenylcyclohexylamine | C12H17N | CID 31862 - PubChem

   pubchem.ncbi.nlm.nih.gov › 1-phenylcyclohexylamine

   Oct 14, 2021 · 1-Phenylcyclohexylamine | C12H17N | CID 31862 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

4. webbook.nist.gov › cgi › cbookN-Phenylcyclohexylamine - NIST Chemistry WebBook

   webbook.nist.gov › cgi › cbook

   • Cached

   Feb 6, 2010 · Molecular weight: 175.2701. IUPAC Standard InChI: InChI=1S/C12H17N/c1-3-7-11 (8-4-1)13-12-9-5-2-6-10-12/h1,3-4,7-8,12-13H,2,5-6,9-10H2. IUPAC Standard InChIKey: TXTHKGMZDDTZFD-UHFFFAOYSA-N. CAS Registry Number: 1821-36-9. Chemical structure: This structure is also available as a 2d Mol file or as a computed 3d SD file.

5. analyticalsciencejournals.onlinelibrary.wiley.comPreparation and analytical characterization of 1‐(1 ...

   analyticalsciencejournals.onlinelibrary.wiley.com

   Apr 2, 2013 · Preparation and analytical characterization of 1‐ (1‐phenylcyclohexyl)piperidine (PCP) and 1‐ (1‐phenylcyclohexyl)pyrrolidine (PCPy) analogues - Wallach - 2014 - Drug Testing and Analysis - Wiley Online Library.

   • Author: Jason Wallach, Giorgia De Paoli, Adeboye Adejare, Simon D. Brandt
   • Cited By: 19

   • Publish Year: 2014
   • Published: 02 April 2013

6. link.springer.com › referenceworkentry › 10Arylcyclohexamines (Ketamine, Phencyclidine, and Analogues)

   link.springer.com › referenceworkentry › 10

   • Cached

   Jan 1, 2016 · The first arylcyclohexamine to be described was 1-(1-phenylcyclohexyl) amine, in 1907, almost 50 years before the synthesis of PCP . Other analogues reported in the early 1950s included N -ethyl-1-phenylcyclohexylamine (PCE) and 1-(1-phenylcyclohexyl)morpholine (PCMo).

7. www.semanticscholar.org › paper › Synthesis-andSynthesis and anticonvulsant activity of 1 ... - Semantic Scholar

   www.semanticscholar.org › paper › Synthesis-and

   Synthesis and anticonvulsant activity of 1-phenylcyclohexylamine analogues. | Semantic Scholar. DOI: 10.1021/JM00167A027. Corpus ID: 11849936. Synthesis and anticonvulsant activity of 1-phenylcyclohexylamine analogues. A. Thurkauf, B. de Costa, +4 authors. M. Rogawski. Published in Journal of Medicinal… 1 May 1990. Chemistry, Medicine. TLDR.

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9. pubmed.ncbi.nlm.nih.gov › 2329567Synthesis and anticonvulsant activity of 1 ... - PubMed

   pubmed.ncbi.nlm.nih.gov › 2329567

   Abstract. Thirty-eight analogues of 1-phenylcyclohexylamine (PCA), a phencyclidine (PCP) derivative, were examined for their activities in the mouse maximal electroshock (MES) seizure test and in a motor-toxicity assay. In addition, we determined the binding affinities of the compounds for PCP acceptor sites in rat brain membranes labeled with ...

10. www.sciencedirect.com › science › articleStructure-guided design and synthesis of P1′ position 1 ...

    www.sciencedirect.com › science › article

    Sep 1, 2011 · Structure-guided design and synthesis of P1′ position 1-phenylcycloalkylamine-derived pentapeptidic BACE1 inhibitors - ScienceDirect. Volume 19, Issue 17, 1 September 2011, Pages 5238-5246. Structure-guided design and synthesis of P 1 ′ position 1-phenylcycloalkylamine-derived pentapeptidic BACE1 inhibitors. Harichandra D. Tagad a. ,