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  1. 5 days ago · Clostridia cause several important toxin-mediated diseases, including tetanus (Clostridium tetani), botulism (C. botulinum), gas gangrene (C. perfringens), and antibiotic-associated diarrhea and pseudomembranous colitis (C. difficile).

  2. 3 days ago · In 1917, Bacillus botulinus was renamed Clostridium botulinum, as it was decided that term Bacillus should only refer to a group of aerobic microorganisms, while Clostridium would be only used to describe a group of anaerobic microorganisms. [97]

  3. Sep 11, 2024 · The bacterium Clostridium botulinum, well-known for producing botulinum neurotoxins, which cause the severe paralytic illness known as botulism, produces C2 toxin, a binary AB-toxin with...

  4. Aug 31, 2024 · Botulinum toxin was discovered in 1895 by Belgian bacteriologist Émile Pierre van Ermengem following an outbreak in the Belgian village of Ellezelles, where a group of local musicians who had consumed smoked ham at a gathering fell ill with symptoms of “sausage poisoning”—the translation of the German Botulismus, from which the term ...

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  5. Sep 13, 2024 · Botulism is a severe paralytic illness caused by the neurotoxin produced by spores of the bacterium, Clostridium botulinum. There are four naturally occurring forms of botulism (foodborne, wound, infant/intestinal, and adult intestinal toxemia) and two other forms (inhalation and iatrogenic).

  6. Sep 11, 2024 · Toxin Production. Clostridium botulinum is renowned for producing botulinum neurotoxin (BoNT), the most potent toxin known, which causes botulism, a life-threatening paralytic illness 4. The production of BoNT is regulated by complex genetic and environmental factors, including the Spo0A regulator, which also controls sporulation.

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  8. Sep 14, 2024 · botulism, paralytic syndrome caused by poisoning by botulinum toxin, a substance produced by Clostridium botulinum bacteria. Botulism results most frequently from the eating of improperly sterilized home-canned foods containing the toxin. Poisoning also may result from wound infection.

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