Search results
Mar 24, 2002 · César Milstein. The Nobel Prize in Physiology or Medicine 1984. Born: 8 October 1927, Bahia Blanca, Argentina. Died: 24 March 2002, Cambridge, United Kingdom. Affiliation at the time of the award: MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
Jun 1, 2002 · In memoriam: César Milstein, who with the late Georges Köhler invented monoclonal antibodies, died on 24 March 2002. Their invention sprang from basic research on antibody diversity and...
César Milstein was awarded the 1984 Nobel Prize in Physiology or Medicine jointly with his former postdoctoral fellow Georges J. F. Köhler (AAI '85) and theoretician Niels Jerne (AAI '73). Milstein and Köhler won the prize for developing the hybridoma method of producing monoclonal antibodies.
May 1, 2002 · Cesar Milstein, one of the key figures in the development of monoclonal antibodies, died on 24 March 2002 at the age of 74. Together with Georges Köhler, Milstein reported a hybridoma technique...
Apr 25, 2002 · César Milstein began to study antibody diversity at a time when almost nothing was known about its molecular and genetic basis. As a logical step in that work, with Georges Köhler he devised...
He focused on antibodies, the proteins produced by mature B lymphocytes (plasma cells) as part of the immune response. Milstein used myeloma cells, cancerous forms of plasma cells that multiply indefinitely, to study somatic hypermutation and the mechanism by which antibody diversity is generated.
César Milstein held his Nobel Lecture on 8 December 1984, at Karolinska Institutet, Stockholm. He was presented by Professor Hans Wigzell of the Karolinska Institutet. From the Structure of Antibodies to the Diversification of the Immune Response
