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- Season 10 overviewSep 24, 2009-May 20, 201023 episodesSeason 10 episodes1. Family Affair Sep 24, 2009
- Sara Sidle helps the team investigate when a young actress is killed.
- 2. Ghost Town Oct 1, 2009
- The team investigates an upscale neighborhood when a porn producer and a drug dealer are killed.
- 3. Working Stiffs Oct 8, 2009
- Two officemates plot to rob a casino, but their plan ends with the CSI team investigating a murder.
- 4. Coup de Grace Oct 15, 2009
- When one policeman kills another, the CSIs must determine if it was premeditated.
- 5. Bloodsport Oct 29, 2009
- A popular coach is murdered in his home, and the entire college football team is under suspicion.
- 6. Death and the Maiden Nov 5, 2009
- The CSIs discover that two seemingly unrelated crimes are actually part of a revenge plot.
- 7. The Lost Girls Nov 12, 2009
- The team helps Langston investigate a prostitution ring that may have harbored a hostage.
- 8. Lover's Lanes Nov 19, 2009
- Unusual piece of evidence is revealed during a bowling tournament.
- 9. Appendicitement Dec 10, 2009
- While celebrating Henry's birthday, the CSIs uncover a double homicide.
- 10. Better Off Dead Dec 17, 2009
- The CSIs want to find out how a recent gun-store shootout may be connected to a possible suicide.
- 11. Sin City Blue Jan 14, 2010
- An investigation into the murder of two women at a Las Vegas hotel leads to an unusual killer.
- 12. Long Ball Jan 21, 2010
- The team collects evidence after a legendary golfer is murdered at a high-profile tournament.
- 13. Internal Combustion Feb 4, 2010
- The case of two high school students leads the CSIs into the world of streetcar racing.
- 14. Unshockable Mar 4, 2010
- A member of Rascal Flatts is electrocuted by his own guitar during a concert.
- 15. Neverland Mar 11, 2010
- When a boy is murdered, the team uncovers evidence that could link his death to an old case.
- 16. The Panty Sniffer Apr 1, 2010
- Detective Vartann and Catherine grow closer during a 24-hour stakeout in an upscale hotel.
- 17. Irradiator Apr 8, 2010
- A murder investigation brings Langston one step closer to catching a serial killer.
- 18. Field Mice Apr 15, 2010
- When Hodges and Wendy take a group of students on a field trip, they embellish their roles.
- 19. World's End Apr 22, 2010
- Catherine investigates when a student is found murdered at her daughter's school.
- 20. Take My Life, Please! Apr 29, 2010
- When two legendary comics reunite for a Las Vegas performance, one of them ends up dead.
- 21. Lost & Found May 6, 2010
- A mother, believed to be grieving, becomes a suspect in an investigation.
- 22. Doctor Who May 13, 2010
- A former colleague accuses Langston of being part of the Dr. Jekyll murders.
- 23. Meat Jekyll May 20, 2010
- A murderer holds the key to the identity of the Dr. Jekyll serial killer.