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- Season 5 overviewOct 7, 2021-May 19, 202222 episodesSeason 5 episodes1. One Bad Night and Chaos of Selfish Desires Oct 7, 2021
- Sheldon and Missy both run away from home; Mary gets upsetting news about George Sr.
- 2. Snoopin' Around and the Wonder Twins of Atheism Oct 14, 2021
- Sheldon encourages Missy to question the Bible; Meemaw is determined to catch George Sr. in a lie.
- 3. Potential Energy and Hooch on a Park Bench Oct 21, 2021
- Sheldon wants Dr. Sturgis to return to the university; Georgie makes a life-changing decision.
- 4. Pish Posh and a Secret Back Room Oct 28, 2021
- Sheldon, Missy and Georgie adapt to new living arrangements; Meemaw opens a gambling room.
- 5. Stuffed Animals and a Sweet Southern Syzygy Nov 4, 2021
- Sheldon and Dr. Linkletter struggle to solve an equation; George Sr. gives Missy advice.
- 6. Money Laundering and a Cascade of Hormones Nov 11, 2021
- Missy asks some uncomfortable questions at church; Meemaw and Georgie go into business together.
- Sheldon takes his first engineering class with Professor Boucher.
- 8. The Grand Chancellor and a Den of Sin Dec 2, 2021
- Sheldon battles President Hagemeyer's mysterious boss over the university's science requirements.
- 9. The Yips and an Oddly Hypnotic Bohemian Dec 9, 2021
- Sheldon gets the science yips and has to learn how to not think; George Sr. plays handyman.
- 10. An Expensive Glitch and a Goof-Off Room Jan 6, 2022
- Sheldon gets a dorm room all to himself; Meemaw gains an unwanted business partner.
- 11. A Lock-In, a Weather Girl and a Disgusting Habit Jan 13, 2022
- Sheldon acts as Mary's spy during a youth lock-in at church; Georgie is attracted to an older woman.
- 12. A Pink Cadillac and a Glorious Tribal Dance Jan 20, 2022
- Sheldon attends his first comic book convention; Mary tries selling makeup.
- 13. A Lot of Band-Aids and the Cooper Surrender Jan 27, 2022
- Sheldon makes friends with his dorm neighbors; George Sr. learns his job is in jeopardy.
- 14. A Free Scratcher and Feminine Wiles Feb 24, 2022
- Sheldon butts heads with Dr. Lee, a new scientist in the lab; Mary is given a lotto ticket.
- Sheldon joins Dr. Linkletter and Dr. Sturgis on a road trip.
- 16. A Suitcase Full of Cash and a Yellow Clown Car Mar 10, 2022
- Meemaw's gambling room becomes a success; Sheldon dips his toe in the stock market.
- 17. A Solo Peanut, a Social Butterfly and the Truth Mar 31, 2022
- Sheldon gets an odd request from a friend; Georgie comes clean to Mandy.
- 18. Babies, Lies and a Resplendent Cannoli Apr 14, 2022
- Sheldon copes with the death of a hero; Missy wants to babysit; Georgie struggles with his secret.
- 19. A God-Fearin' Baptist and a Hot Trophy Husband Apr 21, 2022
- George and Mary want to meet the new woman in Georgie's life; Sheldon and Missy have suspicions.
- 20. Uncle Sheldon and a Hormonal Firecracker Apr 28, 2022
- Sheldon and Missy learn about Georgie's pregnancy, and the whole family vows to keep it a secret.
- 21. White Trash, Holy Rollers and Punching People May 12, 2022
- As the church congregation gossips about Georgie, Missy stands up for her brother.
- 22. A Clogged Pore, a Little Spanish and the Future May 19, 2022
- Sheldon struggles to cope with his first signs of puberty; Georgie and Meemaw take a business trip.