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- Season 1 overviewNov 16, 2004-May 24, 200522 episodesSeason 1 episodes1. Pilot Nov 16, 2004
- Dr. House and his team try to save the life of a kindergarten teacher.
- 2. Paternity Nov 23, 2004
- Dr. House and the team think a teenage lacrosse player has multiple sclerosis.
- 3. Occam's Razor Nov 30, 2004
- A collegian collapses; House and his team scramble to figure out why.
- 4. Maternity Dec 7, 2004
- Dr. House annoys his boss when he suggests that two sick newborns in the hospital begin an epidemic.
- 5. Damned if You Do Dec 14, 2004
- Dr. House's approach raises questions when he treats a nun for what he believes is an allergy.
- 6. The Socratic Method Dec 21, 2004
- Dr. House shows special interest in a schizophrenic with deep-vein thrombosis and her teenage son.
- 7. Fidelity Dec 28, 2004
- House suspects a rare sexually transmitted disease when a housewife falls ill.
- 8. Poison Jan 25, 2005
- House and his team investigate the mysterious poisoning of a high-school student.
- 9. DNR Feb 1, 2005
- House violates the DNR order of a musician and saves his life.
- 10. Histories Feb 8, 2005
- Dr. Foreman believes an uncooperative homeless woman is faking seizures.
- 11. Detox Feb 15, 2005
- House agrees to stop taking painkillers for a week in exchange for a month without clinic duty.
- 12. Sports Medicine Feb 22, 2005
- A severely broken arm reveals underlying problems for a major league pitcher.
- 13. Cursed Mar 1, 2005
- The team tries to treat the son of a demanding financial supporter of the hospital.
- 14. Control Mar 15, 2005
- Billionaire entrepreneur Edward Vogler buys his way into becoming chairman of the board.
- 15. Mob Rules Mar 22, 2005
- When a mob informant suddenly collapses before court, House is called upon to cure him.
- 16. Heavy Mar 29, 2005
- House and his team blame a reaction to diet pills after an obese girl has a heart attack.
- 17. Role Model Apr 12, 2005
- When Sen. Tom Wright becomes ill, House examines him and finds that the symptoms point toward AIDS.
- 18. Babies & Bathwater Apr 19, 2005
- House and his team scramble to find the cause of kidney and brain dysfunction in a pregnant patient.
- 19. Kids May 3, 2005
- A meningitis scare overwhelms the resources and staff of the hospital.
- 20. Love Hurts May 10, 2005
- The team tries to discover what is causing a young man to have blood clots and strokes.
- 21. Three Stories May 17, 2005
- A woman from Dr. House's past returns for his help in a diagnosis.
- 22. Honeymoon May 24, 2005
- While House works to save Stacy's husband, he must deal with his feelings for her.