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Henri Laborit (21 November 1914 – 18 May 1995) was a French surgeon, neurobiologist, writer and philosopher. In 1952, Laborit was instrumental in the development of the drug chlorpromazine, published his findings, and convinced three psychiatrists to test it on a patient, resulting in great success. Laborit was recognized for his work, but as ...
Henri Laborit was one of the founders of modern neuropsychopharmacology, having discovered, or participated in, the discovery of chlorpromazine, gamma-OH, clomethiazole, and minaprine. He also put forward a theory regarding the necessity of counteracting the negative consequences of defense mechanisms during anesthesia or behavioral inhibition.
- Edward Kunz
- 10.31887/DCNS.2014.16.1/ekunz
- 2014
- 2014/03
Henri Laborit, né le 21 novembre 1914 à Hanoï, alors en Indochine française, et mort le 18 mai 1995 à Paris, est un médecin chirurgien et neurobiologiste . Il introduit en 1951 l'utilisation des neuroleptiques, révolutionnant la psychiatrie, et celle du GHB en 1960, révolutionnant l' anesthésie.
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Henri Laborit was a surgeon who found that chlorpromazine, a drug used to reduce surgical shock, also had a calming effect on his patients. He shared his discovery with Pierre Deniker, a psychiatrist who tested the drug on severely ill patients and convinced the U.S. to approve it.
One research group at Rhône Poulenc, headed by the chemist Paul Charpentier (n.d.), was trying to create an improved antihistamine loosely modeled on diphenhydramine, which was already known and is today the active ingredient in such drugs as Benadryl, Dramamine, and Sominex.
Henri Laborit was one of the founders of modern neuropsychopharmacology, having discovered, or participated in, the discovery of chlorpromazine, gamma-OH, clomethiazole, and minaprine.
Henri Laborit (1914-1995) was a French military MD. He contributed to the discovery of an important molecule that has changed the face of psychiatry, namely chlorpromazine, which became the first drug in the class of first-generation antipsychotics, which later led to the dopamine hypothesis of schi ….
