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- Elion and her team developed drugs to combat leukemia, herpes and AIDS. They also discovered treatments to reduce the body's rejection of foreign tissue in kidney transplants between unrelated donors.
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Apr 2, 2014 · American biochemist and pharmacologist Gertrude B. Elion helped develop drugs to treat leukemia and prevent kidney transplant rejection. She won a Nobel Prize for medicine in 1988.
The drugs they developed are used to treat a variety of maladies, such as leukemia, malaria, lupus, hepatitis, arthritis, gout, [25] organ transplant rejection ( azathioprine ), as well as herpes ( acyclovir, which was the first selective and effective drug of its kind). [26]
Feb 21, 1999 · During the 1950s, Elion, together with George Hitchings, developed a systematic method for producing drugs based on knowledge of biochemistry and diseases. One of the first drugs produced by the pair was for leukemia and helped many children with the disease to survive.
In 1957 their alteration of 6MP produced the compound azathioprine, which proved useful in treating severe rheumatoid arthritis and other autoimmune disorders and in suppressing the body’s rejection of transplanted organs. Their new drug allopurinol was an effective treatment for gout.
- The Editors of Encyclopaedia Britannica
I was highly motivated to do something that might eventually lead to a cure for this terrible disease. When I entered Hunter College in 1933, I decided to major in science and, in particular, chemistry.
Jun 3, 2021 · When she was a teenager, her grandfather died of stomach cancer, prompting Elion to study science in search of a drug to cure cancer. She attended Hunter College on a full merit scholarship – a necessity as the stock market crash of 1929 left her family bankrupt.
On the Road to the Nobel. In addition to 6-MP, Elion went on to discover a series of drugs that attack the life cycle of nucleic acid, including allopurinol—which inhibits uric acid synthesis, making it a viable treatment for gout—and azathioprine (Imuran), an effective immunosuppressive drug.
