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Abstract. Answering the question as to why we age is tantamount to answering the question of what is life itself. There are countless theories as to why and how we age, but, until recently, the very definition of aging – senescence – was still uncertain.
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Answering the question as to why we age is tantamount to...
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The cumulative effect of ROS over time. ROS accumulation,...
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Smith JR, Pereira-Smith OM. Replicative senescence:...
- Systems Biology in Aging
1. INTRODUCTION. Aging has fascinated researchers since...
- Caloric Restriction in Humans
Aging is associated with an increased risk for metabolic...
- Advanced Glycation End Product Level, Diabetes, and Accelerated Cognitive Aging
Results: Older adults with high pentosidine level had worse...
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Aug 1, 2010 · Modern biological theories of aging in humans fall into two main categories: programmed and damage or error theories. The programmed theories imply that aging follows a biological timetable, perhaps a continuation of the one that regulates childhood growth and development.
- Genetic Theory of Aging
- Theories of Aging
- Genes and Bodily Functions
- How Genes Impact Lifespan
- Key Concepts in The Genetic Theory of Aging
- Three Primary Genetic Theories of Aging
- Evidence Behind The Theory
- Evidence Against Genetic Theories of Aging
- The Bottom Line
- What Can You Do to Reduce The "Genetic" Aging of Your cells?
The genetic theory of aging states that lifespan is largely determined by the genes we inherit. According to the theory, our longevity is primarily determined at the moment of conception and is largely reliant on our parents and their genes. The basis behind this theory is that segments of DNA that occur at the end of chromosomes, called telomere...
There are two primary categories of aging theorieswhich differ fundamentally in what can be referred to as the "purpose" of aging. In the first category, aging is essentially an accident; an accumulation of damage and wear and tear to the body which eventually leads to death. In contrast, programmed aging theories view aging as an intentional proce...
Before discussing the key concepts related to aging and genetics, let's review what our DNA is and some of the basic ways in which genes affect our lifespan. Our genes are contained in our DNAwhich is present in the nucleus (inner area) of each cell in our bodies. (There is also mitochondrial DNA present in the organelles called mitochondria which ...
It doesn't take an elaborate study to determine that our genes play at least some role in longevity. People whose parents and ancestors have lived longer, tend to live longer and vice versa. At the same time, we know that genetics alone are not the sole cause of aging. Studies looking at identical twins reveal that there is clearly something else g...
The key concepts in genetics and aging include several important concepts and ideas ranging from telomere shortening to theories about the role of stem cells in aging.
As noted above, there is a significant amount of evidence that looks at the importance of genes in expected survival. When looking at genetic theories, these are broken down into three primary schools of thought. 1. The first theory claims that aging is related to mutations that are related to long-term survival and that aging is related to the acc...
There are several avenues of evidence that support a genetic theory of aging, at least in part. Perhaps the strongest evidence in support of the genetic theory is the considerable species-specific differences in maximal survival, with some species (such as butterflies) having very short lifespans, and others, such as elephants and whales, being sim...
One of the stronger arguments against a genetic theory of aging or a "programmed lifespan" comes from an evolutionary perspective. Why would there be a specified lifespan beyond reproduction? In other words, what "purpose" is there for life after a person has reproduced and been alive long enough to raise their progeny to adulthood? It's also clear...
It's been estimated that genes can explain a maximum of 35 percent of lifespan, but there is still more we do not understand about aging than which we do understand. Overall, it's likely that aging is a multifactorial process, meaning that it is probably a combination of several of the theories. It's also important to note that the theories discu...
We are taught to eat a healthy diet and be active and these lifestyle factors are likely just as important no matter how much our genetics are involved in aging. The same practices which seem to keep the organs and tissues of our bodies healthy may also keep our genes and chromosomes healthy. Regardless of the particular causes of aging, it can mak...
Jan 1, 2022 · senescence. aging theories. antiaging therapies. stem cell therapy. 1.1. Introduction. Aging is marked by many pathologies, the result of the loss of homeostasis and the accumulation of molecular damage eventually leading to death and biology ( Vijg, 2014 ). The aging of humans involves many changes at various stages.
INTRODUCTION. A number of theories, which fall into two main categories, have been proposed in an attempt to explain the process of aging. The first category is comprised of concepts holding that aging is programmed and those positing that aging is caused by the accumulation of damage.
- P. V. Sergiev, O. A. Dontsova, G. V. Berezkin
- Acta Naturae. 2015 Jan-Mar; 7(1): 9-18.
- 2015
- Jan-Mar 2015
The most widely accepted overall theory of aging is the evolutionary. senescence theory of aging. Unlike the earlier programmed theory of evolution and aging, which tried to findreasonswhyevolutionmight favor aging, evolutionary senes- cence theory focuses on the failure of natural selection to affect late- life traits.
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Khmelnytsky, Yurii. Khmelnytsky, Yurii [Xmel’nyc’kyj, Jurij] (aka Khmelnychenko, Yuras), 1641–85. Hetman of Ukraine (1657, 1659–63) and hetman of Right-Bank Ukraine (1677–81, 1685); the younger son of Bohdan Khmelnytsky. His father, who hoped to establish a hereditary hetmancy, designated him as his successor after the death of his ...
