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- PS is synthesized by replacement of the choline group of PC by serine in a reaction catalyzed by PSS1, and also by replacement of the ethanolamine group of PE by serine in a reaction catalyzed by PSS2. These synthetic reactions occur in the endoplasmic reticulum. PS is decarboxylated to PE in the mitochondria by PS decarboxylase (PSD).
www.ncbi.nlm.nih.gov › pmc › articlesPhosphatidylserine in the Brain: Metabolism and Function - PMC
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Biosynthesis. Biosynthesis of phosphatidylserine. Phosphatidylserine is formed in bacteria (such as E. coli) through a displacement of cytidine monophosphate (CMP) through a nucleophilic attack by the hydroxyl functional group of serine. CMP is formed from CDP-diacylglycerol by PS synthase.
PS synthesis and metabolism in the brain. PS is synthesized by replacement of the choline group of PC by serine in a reaction catalyzed by PSS1, and also by replacement of the ethanolamine group of PE by serine in a reaction catalyzed by PSS2. These synthetic reactions occur in the endoplasmic reticulum.
- Hee-Yong Kim, Bill X. Huang, Arthur A. Spector
- 10.1016/j.plipres.2014.06.002
- 2014
- 2014/10
Nov 20, 2020 · Phosphatidylserine (PS) is an essential anionic phospholipid of cell membranes, and conducts numerous roles for their structural and functional integrity. In mammalian cells, two distinct enzym … Phosphatidylserine biosynthesis pathways in lipid homeostasis: Toward resolution of the pending central issue for decades
- Atsuko K. Kimura, Tomohiro Kimura
- 2021
In mammalian cells, PS is synthesised by a calcium-dependent reaction in which the head group of PC or PE is replaced by serine. The reaction is catalysed by PS synthase 1 (PSS1), which utilises PC, whereas PS synthase-2 (PSS2) uses PE ( Kuge and Nishijima, 1997) ( Figure 7 ).
Mar 11, 2020 · Abstract. Phosphatidylserine (PS) is an anionic phospholipid found on the membranes of a variety of organelles throughout the cell, most notably the plasma membrane. Under homeostatic conditions, PS is typically restricted to the inner leaflet of the plasma membrane.
Aug 3, 2022 · The biosynthesis, distribution, and degradation of phosphatidylserine. PS is produced in ER (MAM), PSS1 catalyzes PE to PS, PSS2 catalyzes PC to PS. Some new PS is transported to mitochondria, and PS is decarboxylased and forms PE in mitochondria.
- 10.3389/fnagi.2022.975176
- 2022
- Front Aging Neurosci. 2022; 14: 975176.
Dec 23, 2019 · Phosphatidylserine (PS), synthesized in the endoplasmic reticulum (ER) by phosphatidylserine synthase (PSS), is transported to the plasma membrane (PM) and mitochondria through distinct routes. The in vivo functions of PS at different subcellular locations and the coordination between different PS transport routes are not fully understood.
