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4 days ago · A cardinal, still open question is how to define signaling strength . Formally, signal transduction was described as the cell’s response to mitogens (https://cancer.gov/), where the signal propagates from one pathway node to another. However, such description overlooks vital questions including how to determine whether the mitogen-induced ...
1 day ago · After agonist binding, in the final step of signal transduction, receptors in active states exhibit favourable affinities for intracellular coupling partners (e.g., G proteins) (Figure 3d). Such interactions typically trigger conformational changes in the coupling partner and, by this, initiate specific downstream signalling events.
3 days ago · Principle of transduction. The input/output signals (in the form of energy) in a sensor can be divided into six. They are, Mechanical; Thermal; Electrical; Magnetic; Radiant; Chemical; Some of the physical and chemical transduction principles can be grouped according to the form of energy in which signals are received and generated. Mechanical ...
5 days ago · Innate immune pattern recognition receptors, such as the Toll-like receptors (TLRs), are key mediators of the immune response to infection and central to our understanding of health and disease<sup>1</sup>. After microbial detection, these receptors activate inflammatory signal transduction pathways …
3 days ago · Additionally, they play crucial roles as regulators or participants in various cellular functions, such as cellular proliferation, differentiation, signal transduction, and phagocytosis. Over the past four decades of research on Rab proteins, they have garnered significant attention from researchers and numerous noteworthy research findings ...
2 days ago · The signal transduction pathway plays a significant role in sensing high temperatures and adjusting cellular metabolism and function to prevent heat-related damage (Mittler et al. Citation 2012). Ca 2+ is involved in heat shock signal transduction and regulates downstream events in filamentous fungi (Zhang et al. Citation 2016 ).
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2 days ago · Definition. An oncogene is a mutated gene that has the potential to cause cancer. Before an oncogene becomes mutated, it is called a proto-oncogene, and it plays a role in regulating normal cell division. Cancer can arise when a proto-oncogene is mutated, changing it into an oncogene and causing the cell to divide and multiply uncontrollably.
