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- Season 10 overviewNov 3, 2021-Feb 9, 202215 episodesSeason 10 episodes15. David's Journey Feb 9, 2022
- David searches for the motivation to change and save his own life.
- 14. Lisa's Journey Feb 2, 2022
- When Randy falls ill, Lisa finds out if she has the will and determination to turn her life around.
- 13. Larry's Journey Jan 26, 2022
- For Larry, weight-loss surgery would mean a second chance being a gospel recording artist.
- 12. Dolly's Journey Jan 19, 2022
- Dolly has pain all over, and the skin apron pulling on her abdomen is miserable.
- 11. Ontreon's Journey Jan 12, 2022
- At 700 pounds, Ontreon has managed to keep going thanks to his faith in God.
- 10. Margaret's Journey Jan 5, 2022
- Margaret's life at 700 pounds is in need of a jump-start; at age 35, she is a mama's girl.
- 9. Lucas' Journey Dec 29, 2021
- Lucas wants to spread his wings and fly, but at 600 pounds, he can't take off.
- 8. James B's Journey Dec 22, 2021
- James needs Dr. Now's help to survive, but a death in the family sends James back to food.
- 7. Ryan's Journey Dec 15, 2021
- Ryan moved to Montana to keep himself from going down a dark path of drug addiction.
- 6. Paul's Journey Dec 8, 2021
- Paul weighs 700 pounds, and his girlfriend struggles with their ability to live a normal life.
- 5. Lacey's Journey Dec 1, 2021
- Lacey is so big that she can barely leave the house, but that hasn't stopped her from finding love.
- 4. Mike's Journey Nov 24, 2021
- Mike was born with a talent for sports and an omnivorous appetite to match.
- 3. Bianca's Journey Nov 17, 2021
- Bianca is all in for a move to Houston with her boyfriend and two young kids.
- 2. Julian's Story Nov 10, 2021
- Julian will have to overcome the food addiction that made him more than 800 pounds.
- 1. Nathan's Journey Nov 3, 2021
- Nathan's weight gets in the way of his job, but changing his life might affect his relationship.