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- Season 5 overviewSep 21, 1996-May 17, 199725 episodesSeason 5 episodes1. Runaway Train Sep 21, 1996
- Sully and Cloud Dancing are aboard a train overtaken by robbers.
- 2. Having It All Sep 28, 1996
- Home and career responsibilities overwhelm Mike; Colleen prepares for medical school.
- 3. Malpractice Oct 5, 1996
- An infant patient's death prompts the parents to sue Mike for malpractice.
- 4. All That Glitters Oct 12, 1996
- College stress leads Colleen to consider being a companion to a renowned singer.
- 5. Die Mexikaner Oct 19, 1996
- A Latina blames Mike for not saving her husband; Robert E. and Grace struggle with a secret.
- 6. Last Dance Oct 26, 1996
- Sully gets an offer to survey Yellowstone; Brian's first date.
- 7. Right or Wrong Nov 2, 1996
- Jake and Preston each want Mike's mayoral endorsement, until she is jailed for treating a fugitive.
- 8. Remember Me Nov 9, 1996
- Jake recognizes a sick old prospector as the father who deserted him.
- 9. Legend Nov 16, 1996
- A gunfighting marshal helps Mike and Sully track down bank robbers who wounded Matthew.
- 10. The Tempest Nov 23, 1996
- A deadly storm approaches as Mike and the residents of Colorado Springs prepare for Thanksgiving.
- 11. Separate but Equal Dec 7, 1996
- Grace and Robert E. want Anthony in the town's all-white school.
- 12. A Place to Die Dec 14, 1996
- Patients treated at Mike's clinic contract a mysterious, deadly disease.
- 13. Season of Miracles Dec 21, 1996
- Brian suffers a crisis of faith during Christmas time when blindness strikes the Rev. Johnson.
- 14. The Dam Jan 11, 1997
- Sully joins others opposed to the building of a dam and lands behind bars.
- 15. Farewell Appearance Jan 25, 1997
- Mike's Uncle Theodore, a concert pianist, pays a surprise visit.
- 16. The Most Fatal Disease Feb 1, 1997
- Consumptive Kid Cole tries to alienate Sister Ruth to spare her the agony of watching him die.
- 17. Colleen's Paper Feb 8, 1997
- Dr. Mike recalls cases for Colleen's medical course; a mysterious ailment fells Andrew.
- 18. A House Divided Feb 15, 1997
- Sully's wealthy friend Daniel falls for Mike and humiliates Sully with an offer of financial help.
- 19. Hostage Feb 22, 1997
- Bank robbers, one wounded, take Mike, Brian and Katie hostage.
- 20. The Body Electric Apr 5, 1997
- Rumors make Mike uneasy about poet Walt Whitman's friendship with Brian.
- 21. Before the Dawn Apr 12, 1997
- Horace attempts suicide after he gets his final divorce papers.
- 22. Starting Over Apr 26, 1997
- Dr. Mike is shocked by her sister's liberal behavior after she joins the women's suffrage movement.
- 23. His Father's Son May 3, 1997
- Sully intervenes when Brian's irresponsible behavior endangers the town.
- 24. Moment of Truth May 10, 1997
- Sully arranges an escape for Cloud Dancing, leading him and the Indian to become wanted men.
- 25. Moment of Truth May 17, 1997
- Sully distracts soldiers, allowing Cloud Dancing to escape and face his nemesis, Sgt. O'Connor.