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- Season 5 overviewSep 16, 2008-May 11, 200924 episodesSeason 5 episodes1. Dying Changes Everything Sep 16, 2008
- Still mourning the death of his girlfriend, Wilson resigns from Princeton Plainsboro.
- 2. Not Cancer Sep 23, 2008
- House and the team investigate a string of deaths centering around a single organ donor.
- 3. Adverse Events Sep 30, 2008
- House and the team take on the case of a struggling artist with an undiagnosed illness.
- 4. Birthmarks Oct 14, 2008
- House attends a funeral; the team tries to diagnose the illness of a woman who was in China.
- 5. Lucky Thirteen Oct 21, 2008
- Thirteen's date falls ill after a night of partying, and House takes on her case.
- 6. Joy Oct 28, 2008
- The team treats a sleepwalking patient experiencing unexplained blackouts.
- 7. The Itch Nov 11, 2008
- House and the team treat an agoraphobic who adamantly refuses to leave his home.
- 8. Emancipation Nov 18, 2008
- An emancipated minor working as a factory manager falls ill on the job.
- 9. Last Resort Nov 25, 2008
- A man willing to kill or die for a diagnosis takes House and several patients hostage.
- 10. Let Them Eat Cake Dec 2, 2008
- A high-profile fitness trainer collapses while shooting an infomercial.
- 11. Joy to the World Dec 9, 2008
- Foreman and Thirteen's relationship progresses; unexpected gift.
- 12. Painless Jan 19, 2009
- House and the team try to diagnose a man's severe, chronic pain.
- 13. Big Baby Jan 26, 2009
- The team takes on the case of a teacher who collapsed after spitting up blood during a class.
- 14. The Greater Good Feb 2, 2009
- House and his staff begin to question their life choices while treating a former cancer researcher.
- 15. Unfaithful Feb 16, 2009
- A priest is admitted to the ER after he sees a bleeding Jesus hovering at his doorstep.
- 16. The Softer Side Feb 23, 2009
- The team treats a teenager who doesn't know that he has genetic mosaicism.
- 17. The Social Contract Mar 9, 2009
- House and the team treat a patient who speaks his mind uncontrollably.
- 18. Here Kitty Mar 16, 2009
- House sets out to disprove the allegations of a nursing home worker who feigns illness.
- 19. Locked In Mar 30, 2009
- A man awakes in a New York hospital after a bicycle accident, unable to move or communicate.
- 20. Simple Explanation Apr 6, 2009
- After spending the last several months caring for her dying husband, a woman collapses.
- 21. Saviors Apr 13, 2009
- Cameron asks House to accept the case of an environmental activist who collapsed at a protest.
- 22. House Divided Apr 27, 2009
- A deaf 14-year-old collapses while competing in a wrestling match.
- 23. Under My Skin May 4, 2009
- House and the team treat a ballerina whose lungs collapse during a performance.
- 24. Both Sides Now May 11, 2009
- House treats a patient whose left brain and right brain operate independently.