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Apr 2, 2013 · Preparation and analytical characterization of 1‐ (1‐phenylcyclohexyl)piperidine (PCP) and 1‐ (1‐phenylcyclohexyl)pyrrolidine (PCPy) analogues - Wallach - 2014 - Drug Testing and Analysis - Wiley Online Library.
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An expedient synthesis of high specific activity tritium labelled 4‐fluoro‐1‐[1‐(2‐thienyl)]cyclohexylpiperidine ([ 3 H]FTCP), a ligand for further characterization of the phencyclidine/NMDA receptor complex.
- Asher Kalir, Habib Edery, Zvi Pelah, D. Balderman, Gila Porath
- 1969
Abstract. Thirty-eight analogues of 1-phenylcyclohexylamine (PCA), a phencyclidine (PCP) derivative, were examined for their activities in the mouse maximal electroshock (MES) seizure test and in a motor-toxicity assay. In addition, we determined the binding affinities of the compounds for PCP acceptor sites in rat brain membranes labeled with ...
- Andrew Thurkauf, Brian De Costa, Shun Ichi Yamaguchi, Mariena V. Mattson, Arthur E. Jacobson, Kenner...
- 1990
1-Phenylcyclohexylamine (PCA), an analog of phenyclidine (PCP) in which the piperidine ring is replaced by a primary amino group, and its conformationally restricted analog 1,1-pentamethylenetetrahydroisoquinoline (PM-THIQ) were potent anticonvulsants in the mouse maximal electroshock (MES) seizure ….
- Michael A Rogawski, A. Thurkauf, S. I. Yamaguchi, K. C. Rice, A. E. Jacobson, M. V. Mattson
- 1989
Sep 7, 2023 · Synthesis and Analgesic Activity of New Analogs of 1- [1-phenylcyclohexyl]piperidine with Modified Structures in its Tricyclic System. Published: 07 September 2023. Volume 57 , pages 656–662, ( 2023 ) Cite this article. Download PDF. Pharmaceutical Chemistry Journal Aims and scope. Maryam Shokrollahi, Seyed Ali Sobhanian, Mohsen Khalili,
Synthesis of PCP from PCA via 1-phenylcyclohexanol (PCOH) The PCOH starting material can be purchased or prepared by reaction of phenyllithium or phenyl grignard with cyclohexanone. This alcohol is then be transformed into the amine by reaction with sodium azide (~90% yield) followed by reduction.
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Feb 6, 2010 · IUPAC Standard InChI: InChI=1S/C12H17N/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h1,3-4,7-8,12-13H,2,5-6,9-10H2 Copy IUPAC Standard InChIKey: TXTHKGMZDDTZFD-UHFFFAOYSA-N ...