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  2. Jun 1, 2023 · Paxlovid (nirmatrelvir/ritonavir) is an antiviral medication that’s FDA approved to treat mild to moderate COVID-19 in certain people. A bad taste in the mouth is Paxlovid’s most commonly reported side effect. Paxlovid’s bad aftertaste has been informally called “Paxlovid mouth.”

  3. Jul 25, 2023 · Paxlovid can cause a lingering bitter or metallic taste as it treats COVID-19. But the side effect doesn’t last long and rarely causes additional health issues.

  4. Aug 23, 2022 · Paxlovid, the FDA-approved antiviral drug to treat COVID-19, can leave a foul taste in the mouth. Experts share why this happens, and if there are any health effects associated with it.

  5. Jun 19, 2024 · “Paxlovid mouth” is the lingering bad taste that some people get while they are taking the antiviral drug Paxlovid for a COVID-19 infection. The taste may last for the duration of Paxlovid treatment—five days—and has been described as bitter or metallic.

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    • kathy.katella-cofrancesco@yale.edu
    • How does Paxlovid work? Paxlovid is an antiviral therapy that consists of two separate medications packaged together. When you take your three-pill dose, two of those pills will be nirmatrelvir, which inhibits a key enzyme that the COVID virus requires in order to make functional virus particles.
    • When should I take Paxlovid? You have to take Paxlovid within five days of developing symptoms. Like all antivirals, Paxlovid works best early in the course of an illness—in this case, within the first five days of symptom onset, says Jeffrey Topal, MD, a Yale Medicine infectious diseases specialist who is involved in determining COVID-19 treatment protocols for Yale New Haven Hospital patients.
    • How often do I take Paxlovid? The standard dose is three Paxlovid pills twice daily for five days for a full course that adds up to 30 pills. It helps that the pills are packaged in a “dose card,” basically a medication blister pack that allows you to punch out the pills as needed.
    • Is Paxlovid similar to Tamiflu? “I think it's a good comparison,” says Dr. Roberts. Tamiflu is an antiviral drug that reduces flu symptoms. Both are prescription-only oral antiviral pills given early in illness.
  6. Jun 1, 2023 · 1. Taste changes (“Paxlovid mouth”) Loss of smell or taste is a well-known symptom of COVID. But this side effect is different from that. As Paxlovid became more widely available, many people began reporting taste changes as a side effect. This experience was coined “ Paxlovid mouth ” by many news outlets.

  7. Nov 6, 2023 · An altered or bad taste in the mouth is the most commonly reported side effect with Paxlovid. People report a bitter or metallic taste (often referred to as “Paxlovid mouth”) that’s hard to get rid of while on treatment.

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