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Apr 28, 2022 · Research to date has provided novel insights into lactate's positive role in multiple brain functions and several brain diseases. Although notable controversies and discrepancies remain, the neurobiological role and the metabolic mechanisms of brain lactate have now been described.
Oct 28, 2016 · Lactate is considered an important metabolite in the human body, but there has been considerable debate about its roles in brain function. Research in recent years has suggested that lactate from astrocytes may be crucial for supporting axonal function, especially during times of high metabolic demands or hypoglycemia.
- Laurel Riske, Rejish K. Thomas, Glen B. Baker, Serdar M. Dursun
- 2017
Mar 8, 2018 · This Review focuses on the emerging roles of lactate in brain function, with a particular focus on the modulation of neuronal excitability, neuronal plasticity and neuroprotection.
- Pierre J Magistretti, Pierre J Magistretti, Pierre J Magistretti, Igor Allaman
- 2018
Jul 24, 2023 · Lactate, a byproduct of exercise and metabolism, plays a significant role in brain development and the differentiation of neural stem cells into specialized neurons. The study reveals that lactate sends signals to these cells, modifying and strengthening neuronal functions.
This review discussed how brain disorders, such as AD and ischemic brain damage, begin and progress. Lactate was found to control the expression of its downstream receptors and transporters in the brain, acting as both an energy substrate and a signaling agent.
- Ruobing Li
Lactantius and Eusebius invoke the rhetoric of God’s punishment as evidence of his judgment and his wrath in what they deem to be an appropriate context; elsewhere each writer makes a significantly different claim about the existence and function of divine emotions.
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Oct 12, 2022 · Lactate also has anti-inflammatory effects and promotes immune tolerance and as a signaling molecule plays a major role in memory formation and neuro-protection, wound healing, ischemic tissue injury, cancer growth, and cancer metastasis. Join millions of students and clinicians who learn by Osmosis! Start Your Free Trial. What is lactic acidosis?
