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  1. Jan 17, 2023 · The last case was in 1951 in France, when somebody sold infected bread with the fungus in it. A whole town went hysterical and a 14-year-old girl tried to kill her mother with a carving...

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    • Fact: There Is A Zombie Fungus — in Ants
    • Fact: Some Fungus Can Affect Human Brains and Behavior
    • Fiction: Mind-Controlling Zombie Fungus Can Make The Jump Into Humans
    • Fact: There Is No Vaccine For Killer Fungus
    • Fiction: Human Bites and 'Tendrils' Spread Killer Fungus
    • Fact: Rising Temperatures Could Increase The Threat of Fungal Pathogens

    Zombies in "The Last of Us" bloom with tendrils of a fungus called Cordyceps, which sprout from their heads and mouths, reaching out for fresh victims. Cordyceps is real, but it only overtakes the brains and bodies of insects — most famously, ants. The fungus grows inside an ant's body, causes the ant to climb upwards, and then sprouts from its hea...

    Perhaps the most obvious example is psilocybin, the hallucinogenic compound in magic mushrooms. The fungus ergot also has a reputation for altering the human mind. Some historians attribute the Salem Witch Trials to ergot poisoning, saying that women began behaving strangely and accusing each other of witchcraft after eating infected rye. The psych...

    Fungal diseases can jump from animals to humans. But the idea that a fungus like Cordyceps could mutate enough to make the giant leap from insects to humans, and still keep its ability to effectively manipulate behavior, is far-fetched. In the infectious-disease world, "never say never," Chiller said. "But I will say that there's a lot, a lotof hur...

    In "The Last of Us," the first cases of fictional human Cordyceps appear in Jakarta, Indonesia, where the government asks a leading mycologist to identify the fungus under a microscope and wriggling in the mouth of a dead civilian. Horrified, she learns that 14 people who worked with the victim have disappeared. "There is no medicine. There is no v...

    In the HBO series, zombies have to bite their victims or inject tendrils of fungus into them in order to spread the disease. That's not at all how fungal transmission works in real life. Fungal infections largely spread through touch or surfaces — think of athlete's foot or ringworm. That's why Hughes doesn't think fungi pose a pandemic threat. "Th...

    Mysteriously, Candida auris outbreaks emerged independently on three different continents at the same time in the 2010s. There was no clear link or contact between the outbreaks. Some scientists believethe connecting thread is climate change. As global temperatures rise, fungi have to adapt just like everything else. As more fungi adapt to higher t...

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    • The Last of Us is about grief, zombie-like infecteds and tribalism. The Last of Us centers on Joel, a man with a past that will likely haunt him forever.
    • You shouldn't play The Last of Us game first. Gamers who played The Last of Us Part I have been excited for the series adaptation for a while, but don't let that make you think you should play it immediately.
    • The Last of Us' cast is superb. As noted above, Pedro Pascal leads up The Last of Us' cast as Joel, a man who is primarily trying to find his brother Tommy (Gabriel Luna), a former soldier who's missing in the pandemic-ravaged wasteland.
    • The Last of Us is different from the game. I'm a nerd, so I say the following out of kindness and respect. To all my fellow nerds who loved The Last of Us game, get ready for something that's different.
  3. Aug 22, 2022 · A sequel to the game, The Last of Us Part II, came out in 2020, though it’s unclear if the HBO series will include that part of the story down the road. If you want to know more about the story the upcoming TV series is based on, you have a few options.

  4. Based on the video game franchise developed by Naughty Dog, the series is set twenty years into a pandemic caused by a mass fungal infection, which causes its hosts to transform into zombie -like creatures and causes the collapse of society.

  5. Jan 18, 2023 · HBO’s latest hit, and the game that it’s based on, might sound like pure science fiction, but it’s actually based on real, horrifying science. The developer behind “The Last of Us,” Naughty Dog, took inspiration for its fungal zombies from the cordyceps fungus.

  6. Dec 5, 2022 · The Last of Us is set in 2033, 20 years after the world’s population has been decimated by a fungal infestation of the brain that initially makes its victims violently insane and feral, and...

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