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- On May 6, 2011, ABC canceled the series after five seasons.
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- Sally Field (Nora Walker) The veteran actress was already an Oscar winner (and two-time nominee) by the time she joined the cast of Brothers and Sisters.
- Calista Flockhart (Kitty Walker) Famous for her breakout role on Ally McBeal, Calista Flockhart made her big return to television as conservative pundit Kitty Walker on the ABC drama.
- Matthew Rhys (Kevin Walker) Before starring in the FX series The Americans, along with his now wife Keri Russell, Matthew Rhys was everyone's favorite lawyer Kevin Walker.
- Rachel Griffiths (Sarah Walker) Rachel Griffiths' acting career has spanned over two decades and included hit films such as My Best Friend's Wedding, Blow, and Step Up.
- Sally Field as Nora Walker. Sally Field portrayed the family matriarch Nora Walker. She was one of only two characters to appear in every series episode.
- Dave Annable as Justin Walker. Dave Annable played the youngest Walker son, Justin. Justin was born later in life than the rest of his siblings and often felt over-protected by them and his mother.
- Calista Flockhart as Kitty McCalister. Calista Flockhart portrayed the second-oldest daughter, Kitty Walker McCalister. Technically, she was the first child of William and Nora since William wasn’t Sarah’s biological father.
- Rachel Griffiths as Sarah Walker. Rachel Griffiths played Sarah Walker, the oldest Walker child. Sarah was the epitome of a businesswoman and often struggled to balance her career with her family duties, especially when Paige and Cooper were younger.
May 16, 2011 · Brothers & Sisters. Exclusive: Find Out What Would've Happened to the Walkers in Season 6. Somewhere, the Walkers are drinking a lot of wine — as are their fans. In early May, ABC dropped the...
- Vlada Gelman
The fifth and final season of Brothers & Sisters premiered on September 26, 2010, and concluded May 8, 2011. Season five takes place one year after the events of the season four finale "On the Road Again". This season featured the show's 100th episode with the airing of episode 13.
Jan 29, 2024 · Rob Lowe became the host of new game show The Floor. ABC & Jon Kopaloff/Getty. Veteran actor Rob Lowe joined the cast of "Brothers and Sisters" as Republican Sen. Robert McCallister. His character marries Kitty Walker and eventually dies in a car crash, due to Lowe's wish to depart from the series.
Brothers & Sisters is produced by Berlanti Television, After Portsmouth, and Touchstone Television (Fall 2006–Spring 2007), which is now ABC Studios (Fall 2007–2011). On May 13, 2011, ABC canceled the series after five seasons.
The storyline followed the final demise of Ojai Foods and the discovery of Narrow Lake (an untapped aquifer that made the family rich), as well as the rocky relationship of the finally-married Justin and Rebecca and the politically volatile Kitty and Robert.
