Search results
An arylcyclohexylamine is composed of a cyclohexylamine unit with an aryl moiety attachment. The aryl group is positioned geminal to the amine. In the simplest cases, the aryl moiety is typically a phenyl ring, sometimes with additional substitution. The amine is usually not primary; secondary amines such as methylamine or ethylamine, or ...
Dec 8, 2022 · Arylcyclohexylamine (ACH) derivatives, such as ketamine, are of particular concern, given their rapidly increasing use and the absence of detailed toxicity data. Although ketamine is currently the best-known member of the ACH family, the latter’s history began with the lead compound phencyclidine (PCP).
- 10.3390/ijms232415574
- 2022/12
- Int J Mol Sci. 2022 Dec; 23(24): 15574.
Jan 1, 2022 · Arylcyclohexamines are a group of substances that exhibit dissociative effects due primarily to antagonism of the N-methyl-d-aspartate (NMDA) receptor. Many arylcyclohexamines have been studied in animal and human populations as effective alternatives to traditional inhalational and intravenous anaesthetic agents, and have now become drugs of ...
Arylcyclohexylamines are believed to produce their effects primarily by antagonism of NMDA receptors. Antagonism of the NMDA receptor confers anesthetic, anticonvulsant (seizure-preventing), and dissociative effects. Contrary to popular belief, most arylcyclohexylamines do not significantly inhibit re-uptake of dopamine or agonise μ-opioid ...
Mar 14, 2024 · Paradoxical reactions can be also be caused by excess inflammation caused by an underlying condition (like diabetes), the aftermath of an infection (like Covid-19, malaria or influenza) or even from environmental toxins like mold. Even medications and supplements designed to reduce inflammation often target the wrong kind of inflammation and ...
Jul 2, 2020 · Here are some of the most common antihistamine side effects that you should know about. 1. Sedation. Feeling drowsy or sleepy is one of the most common antihistamine side effects, especially in ...
People also ask
Are arylcyclohexylamine derivatives toxic?
Do arylcyclohexylamines inhibit re-uptake of -opioid receptors?
Is arylcyclohexylamine a psychoactive substance?
How do arylcyclohexylamines work?
Jan 1, 2022 · The arylcyclohexamines are a group of psychoactive agents broadly derived from a cyclohexamine unit with an aryl moiety. The major agents in this group include phencyclidine , ketamine and methoxetamine , which expand into analogues and derivative agents.
