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- As we detail in this review, the ENIGMA Consortium has made multiple, seminal contributions to neuroscience and psychiatry, including (a) characterization of robust neuroimaging profiles for various brain disorders, (b) standardization of metrics used to assess clinical symptoms of patients across multiple research sites, and (c) use of dimensional approaches that go beyond the case–control comparisons of individuals with categorical diagnoses, and further enable the investigation of specific...
Mar 20, 2020 · Anatomical or genetic clustering is yet another methodological improvement implemented by ENIGMA, that can be used widely to enhance detection of genetic associations in multiple...
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May 29, 2020 · Identifying measurable indicators of brain processes associated with MDD could facilitate the detection of individuals at risk, and the development of novel treatments, the monitoring of...
- Lianne Schmaal, Elena Pozzi, Tiffany C Ho, Tiffany C Ho, Laura S van Velzen, Ilya M Veer, Nils Opel,...
- 2020
Jan 1, 2017 · ENIGMA's genetic and disease-related studies are discovering new factors that affect the brain throughout life, how the diseased brain differs from the healthy brain, and how patterns of brain measures differ from one disease to another.
- Paul M. Thompson, Ole A. Andreassen, Alejandro Arias-Vasquez, Carrie E. Bearden, Premika S. Boedhoe,...
- 10.1016/j.neuroimage.2015.11.057
- 2017
- 2017/01/01
Mar 20, 2020 · As the sample size of brain scans in the ENIGMA Consortium increased beyond 50,000 MRI scans, it became possible to discover further genetic loci associated with multiple brain traits implicated in brain disorders.
- Paul M Thompson, Neda Jahanshad, Christopher R K Ching, Lauren E Salminen, Sophia I Thomopoulos, Joa...
- 10.1038/s41398-020-0705-1
- 2020
- Transl Psychiatry. 2020; 10: 100.
Jul 21, 2021 · The goal of ENIGMA‐EEG is to elucidate how genetic variants influence communication between brain areas and the connectivity patterns of the network, matching those variants to neurological and psychiatric disorders.
- Dirk J. A. Smit, Ole A. Andreassen, Ole A. Andreassen, Dorret I. Boomsma, Scott J. Burwell, David B....
- 10.1002/brb3.2188
- 2021
- Brain Behav. 2021 Aug; 11(8): e02188.
ENIGMA’s genetic studies are now analyzing imaging and genetics data from more than 50,000 people to uncover genetic markers that most robustly associated with brain
Jan 27, 2021 · The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) consortium brings together researchers from around the world to try to identify the genetic underpinnings of brain structure and function, along with robust, generalizable effects of neurological and psychiatric disorders.
