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- They jointly published a paper in 1890 proposing a blood serum therapy to induce immunity for tetanus and also for diphtheria. The following year Behring worked with Doctor Erich Wernicke, carrying out experiments on guinea pigs. They were successful in immunizing guinea pigs against diphtheria.
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Feb 28, 2017 · One week later, Behring published a single-author paper on immunization of guinea pigs with inactivated Corynebacterium diphtheriae and diphtheria toxin and on protective activity of serum from immune animals ( 2 ). He concluded his paper stating that “The possibility of cures for even highly acute diseases can thus no longer be ignored.”
- Stefan H. E. Kaufmann
- 10.1128/mBio.00117-17
- 2017
- mBio. 2017 Jan-Feb; 8(1): e00117-17.
- Youth and Education
- Investigations on Iodoform
- Diphteria and Tuberculosis
- Disinfectants and Tetanus
- A Diphterapy Serum
- The Nobel Prize in Medicine
Behring was born “Adolf Emil Behring” in Hansdorf (now Ławice, Iława County), Province of Prussia, now Poland, as son of the teacher Georg August Behring and his second wife Augustine Zech. A scholarship from the Prussian state enabled him to complete his high school diploma. He attended the Army Medical College at Berlin starting from 1874. This m...
In the early 1880s, Emil von Behring performed investigations on iodoform and explained that while the compound does not actually kill the microbes, it possible neutralizes their poisons, being antitoxic. The military health department was especially interested in Behring’s works and sent him to the pharmacologist Carl Binz at Bonn for further trai...
Emil von Behring is best known for his work on diphtheria and tuberculosis. In general, research on the matter probably dates back to Roux and Yersin, both working at the Pasteur Institute in Paris. They were able to show that certain filtrates of diphtheria cultures contained something they called a toxin and produced symptoms of diphtheria. In 18...
Behring intended to build on his work on iodoform and wanted to find out the consequences of injecting animals with material that had been treated with various disinfectants. The experiments were performed with tetanus bacilli and diphtheria, and let to the therapy of both diseases. Behring and Kitasato were able to show in 1890 that small doses of...
The cooperation of his colleagues Paul Ehrlich and Erich Wernickemade a decisive contribution to the development of an effective healing serum. The basic idea behind the blood serum therapy carried out by Behring and his Berlin colleagues is based on the assumption that it is possible to combat infectious pathogens with antitoxins rather than disi...
Von Behring is believed to have cheated Paul Ehrlich out of recognition and financial reward in relation to collaborative research in diphtheria. The two men developed a diphtheria serum by repeatedly injecting the deadly toxin into a horse. The serum was used effectively during an epidemic in Germany. A chemical company preparing to undertake comm...
Over the following years Behring and Wernicke succeeded in immunising guinea pigs against diphtheria. ^is was a difficult procedure requiring a high degree of endurance, diligence and skilfulness [8]. Wernicke managed the practical experiments and wrote them down meticulously in a minute book [9]. Behring however directed the experiments and ...
They had injected diphtheria and tetanus toxins into guinea-pigs, goats and horses; when these animals developed immunity, they derived antitoxins (now known to contain antibodies) from their serum. This process would be called serum therapy by him at the time as he described it as a way to induce permanent immunity or "to stimulate the body's ...
Dec 1, 2022 · Behring noticed that when he injected diphtheria bacteria into rats, guinea pigs, and rabbits, their blood could neutralize the toxin after they fought the disease. Additionally, when he transferred the serum from those immunized animals into non-immunized animals, the second group of animals also received protection against the disease.
The diphtheria poison gets into the blood stream by way of the lymphatic vessels and starts up inflammatory processes from there in the various organs. The inflammatory symptoms are outwardly visible chiefly in the proximity of the site of production, on the pharyngeal mucous membrane and in the larynx. If we now introduce the diphtheria serum ...
Apr 10, 2017 · Emil von Behring (1854–1917) discovered passive immunization as an effective treatment for diphtheria and tetanus. Moreover, he brought this discovery from bench to bedside, and his serum...
