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- Season 5 overviewSep 25, 2008-May 14, 200924 episodesSeason 5 episodes24. Now or Never May 14, 2009
- The doctors band together to save the victim of a traffic accident.
- 23. Here's to Future Days; Now or Never May 14, 2009
- Izzie ponders whether to have a risky procedure; Owen reassesses his place at Seattle Grace.
- 22. What a Difference a Day Makes May 7, 2009
- College students injured in a car accident are admitted to the ER.
- 21. No Good at Saying Sorry (One More Chance) Apr 30, 2009
- Izzie's mother pays her a surprise visit; Thatcher tries to make amends with Meredith and Lexie.
- 20. Sweet Surrender Apr 23, 2009
- While undergoing aggressive cancer treatment, Izzie focuses on planning Meredith's wedding.
- 19. Elevator Love Letter Mar 26, 2009
- Izzie's medical condition requires a difficult surgery; Owen's PTSD episode injures Cristina.
- 18. Stand by Me Mar 19, 2009
- Meredith tries to convince Derek to come back to work; Mark attempts a face transplant surgery.
- 17. I Will Follow You Into the Dark Mar 12, 2009
- Derek decides to quit after learning that more of his patients have died than survived.
- 16. An Honest Mistake Feb 16, 2009
- Derek and Addison face off as they try to save a pregnant patient.
- 15. Before and After Feb 12, 2009
- Addison, Naomi and Sam rush Archer to Seattle Grace, where they reunite with old friends.
- 14. Beat Your Heart Out Feb 5, 2009
- Bailey considers taking her medical career in a new direction.
- 13. Stairway to Heaven Jan 22, 2009
- Everyone in the hospital tries to find a new organ donor for a patient.
- 12. Sympathy for the Devil Jan 15, 2009
- Derek's mother makes a surprise visit and meets Meredith for the first time.
- 11. Wish You Were Here Jan 8, 2009
- Bailey and Seattle Grace's new pediatric surgeon try to save the life of a longtime patient.
- 10. All By Myself Dec 4, 2008
- Lexie is impressed when Mark performs a cutting-edge procedure.
- 9. In the Midnight Hour Nov 20, 2008
- Meredith, Bailey and Cristina help Lexie and Sadie when a routine surgery goes awry.
- 8. These Ties That Bind Nov 13, 2008
- Sadie, one of Meredith's oldest friends, becomes an intern at Seattle Grace.
- 7. Rise Up Nov 6, 2008
- Erica discovers a surprising connection between a surgical resident and a longtime patient.
- 6. Life During Wartime Oct 30, 2008
- Bailey and a team of surgeons must remove a young girl's inoperable tumor.
- 5. There's No I in Team Oct 23, 2008
- Bailey leads a team of doctors performing a string of surgeries.
- 4. Brave New World Oct 16, 2008
- Callie anxiously prepares for her first real date with Erica.
- 3. Here Comes the Flood Oct 9, 2008
- A plumbing leak becomes a flood, causing chaos at Seattle Grace.
- 2. Dream a Little Dream of Me Sep 25, 2008
- A freak ice storm brings trauma patients to Seattle Grace; a military doctor catches Cristina's eye.
- 1. Dream a Little Dream of Me Sep 25, 2008
- A freak ice storm brings trauma patients to Seattle Grace; a military doctor catches Cristina's eye.
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