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Essential features. Congo red stain is the gold standard for the demonstration of amyloid in tissue sections. Used to evaluate the presence and extent of amyloidosis in different organs. Common diseases for Congo red stain include primary amyloidosis, amyloid light chain (AL) seen in plasma cell dyscrasias, amyloid A (AA) associated with ...
In histology and microscopy, Congo red is used for staining in amyloidosis, and for the cell walls of plants and fungi, and for the outer membrane of Gram-negative bacteria. Apple-green birefringence of Congo red stained preparations under polarized light is indicative of the presence of amyloid fibrils.
Jan 1, 2019 · Staining with Congo Red (CR) is a qualitative method used for the identification of amyloids in vitro and in tissue sections. However, the drawbacks and artefacts obtained when using this dye can be found both in vitro and in vivo.
- Elmira I. Yakupova, Liya G. Bobyleva, Ivan M. Vikhlyantsev, Alexander G. Bobylev
- 10.1042/BSR20181415
- 2019
- Biosci Rep. 2019 Jan 31; 39(1): BSR20181415.
Jul 16, 2023 · Purpose : To demonstrate the presence/ absence of Amyloid in a tissue. Control Tissues: FFPE section of known Amyloidosis. Must be sectioned within 8-10 microns. May labs prefer the control and experimental/patient set of slides to be fresh cut (ie sectioned within 24 hours of staining). Staining Pattern:
Since its introduction as a histological stain by Bennhold (1922), Congo red staining of amyloid producing green birefringence when viewed under polarized light has become the diagnostic gold standard for this disorder.
Jan 9, 2022 · Congo red stain is the gold standard for the demonstration of amyloid in tissue sections. It is used to evaluate the presence and extent of amyloid deposits in different organs.
Although Congo red staining has long been accepted as the gold standard for amyloid identification, the interpretation of this stain is not always easy because the staining procedure requires expertise and the use of polarized light microscopy.
