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1. www.neb.com › en › tools-and-resourcesPolymerase Fidelity: What is it, and what does it mean for ...

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   The discovery and development of high-fidelity polymerases has for many years been a key focus at New England Biolabs (NEB). Highfidelity amplification is essential for experiments whose outcome depends upon the correct DNA sequence (e.g., cloning, SNP analysis, NGS applications).

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   What does highfidelity mean?

   • Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free! Can you solve 4 words at once? Get Word of the Day daily email! The meaning of HIGH FIDELITY is the reproduction of an effect (such as sound or an image) that is very faithful to the original.

   High fidelity Definition & Meaning - Merriam-Webster

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   What is polymerase fidelity?

   • Polymerase Fidelity: What is it, and what does it mean for your PCR? The discovery and development of high-fidelity polymerases has for many years been a key focus at New England Biolabs (NEB). Highfidelity amplification is essential for experiments whose outcome depends upon the correct DNA sequence (e.g., cloning, SNP analysis, NGS applications).

   Polymerase Fidelity: What is it, and what does it mean for your PCR? - N…

   www.neb.com/en/tools-and-resources/feature-articles/polymerase-fidelity-what-is-it-and-what-does-it-mean-for-your-pcr

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   Which DNA polymerase has the highest fidelity?

   • The base substitution rates spanned 3 orders of magnitude with the highest fidelity observed for Q5 High-Fidelity DNA Polymerase (5.3 × 10 −7 sub/base/doubling; 280X Taq) and the lowest for exonuclease-deficient Deep Vent (exo-) polymerase (5.0 × 10 −4 sub/base/doubling; 0.3X Taq ).

   Polymerase Fidelity: What is it, and what does it mean for your PCR? - N…

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   How fidelity of DNA replication is maintained?

   • The fidelity of DNA replication, which is the accuracy with which the DNA sequence is copied, is maintained by the action of DNA polymerases, enzymes responsible for adding nucleotides to the new DNA strand.

   Polymerase Fidelity: What is it, and what does it mean for your PCR? - N…

   www.neb.com/en/tools-and-resources/feature-articles/polymerase-fidelity-what-is-it-and-what-does-it-mean-for-your-pcr

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3. www.merriam-webster.com › dictionary › high fidelityHigh fidelity Definition & Meaning - Merriam-Webster

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   Mar 21, 2024 · The meaning of HIGH FIDELITY is the reproduction of an effect (such as sound or an image) that is very faithful to the original.

4. www.ncbi.nlm.nih.gov › pmc › articlesDNA Polymerase Fidelity: Beyond Right and Wrong - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   Nov 1, 2016 · Here we will focus on the structural and mechanistic features of DNA polymerases that allow them the synthesize DNA with high fidelity. Mammalian DNA polymerase beta (pol β), which is involved in base excision repair, is the smallest eukaryotic polymerase.

   • Author: M. Todd Washington
   • DOI: 10.1016/j.str.2016.10.003

   • Publish Year: 2016
   • Published: 2016/11/11

5. www.cell.com › fulltext › S0092-8674(09)00084-1Fidelity at the Molecular Level: Lessons from Protein Synthesis

   www.cell.com › fulltext › S0092-8674(09)00084-1

   Feb 20, 2009 · These studies highlight a common problem in thinking about fidelity in the ribosome: what is the relationship between frameshifting, missense, and nonsense suppression? Should losses in fidelity necessarily affect all three phenomena, or is each process dictated by distinct features of the ribosome?

   • Author: Hani S. Zaher, Rachel Green

   • Publish Year: 2009

6. www.neb.com › high-fidelity-pcr › what-is-fidelityWhat is Fidelity? - NEB

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   The fidelity of a DNA polymerase refers to its ability to accurately replicate a template. A critical aspect of this is the ability of the DNA polymerase to read a template strand, select the appropriate nucleoside triphosphate and insert the correct nucleotide at the 3′ primer terminus, such that canonical Watson-Crick base pairing is ...

7. www.ncbi.nlm.nih.gov › pmc › articlesFidelity at the molecular level: lessons from protein synthesis

   www.ncbi.nlm.nih.gov › pmc › articles

   Feb 2, 2009 · According to their studies, occupancy of the E site with a cognate tRNA species results in a low affinity A site that discriminates effectively against non-cognate tRNA species, whereas an empty E site results in a high affinity and low fidelity A site.

8. www.cell.com › current-biology › fulltextFidelity in protein synthesis: Current Biology - Cell Press

   www.cell.com › current-biology › fulltext

   Jul 26, 2005 · We have discussed two general mechanisms used to maintain the high fidelity of protein synthesis (as well as of DNA replication and transcription). The first mechanism is comprised of editing and kinetic proofreading.