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  1. Due to motor incoordination, muscular weakness, and cretinous dysplasia, cretins have a slow waddling gait. Spasticity of the legs may occasionally make cretins incapable of walking. The skin is often thickened, dry, and scaly, as in simple myxedema (hypothyroidism), sometimes with a brownish hue.

  2. Dermal atrophy is due to thinning of the dermal layer due to loss of collagen and/or elastin. It may occur in aplasia cutis, atophroderma, or following severe inflammatory reactions in the skin affecting the superficial dermis. Atrophy of the panniculus is called lipoatrophy.

  3. Jan 1, 2011 · The very definition of cretinism establishes that we are dealing first and foremost with the thyroid gland. We will expand on its functional behaviour in cretinism in the section on pathological physiology; here we shall restrict ourselves to presenting the clinical findings.

    • John Dennison, Charles Oxnard, Peter Obendorf
    • 2012
  4. The epidermis consists of stratified squamousepithelium. That means it consists of layers of flattened cells. Skin, hair and nails are keratinised, meaning they have a dead and hardened impermeable surface made of a protein called keratin. Mucous membranes are non-keratinised and moist.

  5. Feb 13, 2023 · Zone of stasissurrounds the coagulation zone and is moderately damaged with vascular transudate, elevated vasoconstricting factors, as well as local inflammatory reactions, resulting in impaired tissue perfusion.

    • 10.3390/ijms24043749
    • 2023/02
    • Int J Mol Sci. 2023 Feb; 24(4): 3749.
  6. Apr 2, 2021 · After a brief description of skin pigmentation and skin conditions showing abnormal pigmentation accompanied by aging, this review covers the association between each of the mechanisms implicated in skin aging and skin hyperpigmentation or hypopigmentation to provide a basis for their possible relationship. Figure 1.

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  8. INTRODUCTION. The skin is the largest organ of the body, accounting for about 15% of the total adult body weight. It performs many vital functions, including protection against external physical, chemical, and biologic assailants, as well as prevention of excess water loss from the body and a role in thermoregulation.

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