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- Lead-time bias occurs when an asymptomatic breast cancer is detected by routine screening mammography at an earlier time point in its natural history than when it would have been detected clinically.
academic.oup.com › jnci › articleBeyond survival: a closer look at lead-time bias and disease ...
Dec 25, 2023 · Lead-time bias occurs when an asymptomatic breast cancer is detected by routine screening mammography at an earlier time point in its natural history than when it would have been detected clinically.
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What is lead time and Length bias in breast cancer screening?
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Feb 23, 2022 · We have assessed the impact of lead time bias, which, for breast cancer, is introduced in the presence of mammography screening, on the estimation of loss in life expectancy metrics using a simulation-based approach.
- How to Measure Lives Saved
- Tricky Even For Experienced Doctors
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Because of these biases, the only reliable way to know if a cancer screening test reduces deaths from cancer is through a randomized trial that shows a reduction in cancer deaths in people assigned to screening compared with people assigned to a control (usual care) group. In the NCI-sponsored randomized National Lung Screening Trial (NLST), for ex...
To test community physicians' understanding of screening statistics, Dr. Schwartz, Dr. Steven Woloshin (co-director of the Center for Medicine and Media at The Dartmouth Institute and professor of medicine), and their collaborators from the Max Planck Institute for Human Development in Germany developed an online questionnaire based on two hypothet...
"In some ways these results weren't surprising, because I don't think [these statistics] are part of the standard medical school curriculum," said Dr. Schwartz. "When we were in medical school and in residency, this wasn't part of the training," Dr. Woloshin agreed. "We should be teaching residents and medical students how to correctly interpret th...
Mar 10, 2019 · Survival comparison on Swedish postmenopausal breast cancer cases corrected for lead time bias but not length bias. Using our simulation study we have shown that there is an effect of length-biased sampling of screening cases, not only on tumour growth rate, but also on the symptomatic tumour size.
- Linda Abrahamsson, Gabriel Isheden, Kamila Czene, Keith Humphreys
- 2020
Feb 23, 2022 · Lead time is the extra time added due to early diagnosis, that is, the time from tumour detection through screening to the time that cancer would have been diagnosed symptomatically. It leads to artificially inflated survival estimates even when there are no real survival improvements.
Mar 28, 2024 · One important factor is the bias due to the so-called lead time, i.e., the time by which the diagnosis has been brought forward by screening. Therefore, survival may appear to be longer even if earlier diagnosis did not affect disease progression.
May 25, 2008 · Determination of survival time among persons with screen-detected cancer is subject to lead time and length biases. The authors propose a simple correction for lead time, assuming an exponential distribution of the preclinical screen-detectable period.
