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- Lead-time bias occurs when an asymptomatic breast cancer is detected by routine screening mammography at an earlier time point in its natural history than when it would have been detected clinically.
academic.oup.com › jnci › articleBeyond survival: a closer look at lead-time bias and disease ...
Dec 25, 2023 · In this issue of the Journal, de Munck et al. delve into how to address lead-time bias, adjusting for it while concurrently exploring breast cancer outcomes beyond survival. Lead-time bias occurs when an asymptomatic breast cancer is detected by routine screening mammography at an earlier time point in its natural history than when it would ...
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Should lead time bias be neglected when interpreting trends in breast cancer survival?
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What is lead time bias in mammography?
Oct 13, 2016 · Lead-time bias refers to the overestimation of the duration of survival among women with screening-detected tumors (relative to tumors detected by signs and symptoms) when...
- H. Gilbert Welch, Philip C. Prorok, A. James O’Malley, Barnett S. Kramer
- 2016
Feb 23, 2022 · We have assessed the impact of lead time bias, which, for breast cancer, is introduced in the presence of mammography screening, on the estimation of loss in life expectancy metrics using a simulation-based approach.
- 10.1186/s13058-022-01505-3
- 2022
- Breast Cancer Res. 2022; 24: 15.
Feb 23, 2022 · Lead time is the extra time added due to early diagnosis, that is, the time from tumour detection through screening to the time that cancer would have been diagnosed symptomatically. It leads to artificially inflated survival estimates even when there are no real survival improvements.
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Because of these biases, the only reliable way to know if a cancer screening test reduces deaths from cancer is through a randomized trial that shows a reduction in cancer deaths in people assigned to screening compared with people assigned to a control (usual care) group. In the NCI-sponsored randomized National Lung Screening Trial (NLST), for ex...
To test community physicians' understanding of screening statistics, Dr. Schwartz, Dr. Steven Woloshin (co-director of the Center for Medicine and Media at The Dartmouth Institute and professor of medicine), and their collaborators from the Max Planck Institute for Human Development in Germany developed an online questionnaire based on two hypothet...
"In some ways these results weren't surprising, because I don't think [these statistics] are part of the standard medical school curriculum," said Dr. Schwartz. "When we were in medical school and in residency, this wasn't part of the training," Dr. Woloshin agreed. "We should be teaching residents and medical students how to correctly interpret th...
Nov 20, 2020 · We compared distant recurrence lead time by detection method to DDFI and DDSS, the two component time intervals of disease specific survival, and modeled the relative contribution of detection method to DDFI. We also assessed relative rMBC incidence by detection method.
Lead time has been shown to vary by a woman's age, probably due to alterations in the breast at the menopause making breast cancer more easily detectable by mammography in post-menopausal women or differences in progression rates with age or menopausal status.
