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  1. 1. a. : the quality or state of being changeable : mutability. b. : natural change or mutation visible in nature or in human affairs. 2. a. : a favorable or unfavorable event or situation that occurs by chance : a fluctuation of state or condition. the vicissitudes of daily life.

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  3. Some lives have more vicissitudes than others, to be sure, but no life is without events that test and challenge us. Definitions of vicissitude. noun. a variation in circumstances or fortune at different times in your life or in the development of something.

  4. changes that happen at different times during the life or development of someone or something, especially those that result in conditions being worse: Losing your job is just one of the vicissitudes of life. SMART Vocabulary: related words and phrases. Change and changes. adaptive evolution. adjustment. alteration. anti-evolutionism.

  5. a change or variation occurring in the course of something. interchange or alternation, as of states or things. vicissitudes, successive, alternating, or changing phases or conditions, as of life or fortune; ups and downs: They remained friends through the vicissitudes of 40 years.

  6. one of the many changes and problems in a situation or in your life, that you have to deal with. Definition of vicissitude noun in Oxford Advanced Learner's Dictionary. Meaning, pronunciation, picture, example sentences, grammar, usage notes, synonyms and more.

  7. vicissitude. Definition of vicissitude noun in Oxford Advanced American Dictionary. Meaning, pronunciation, picture, example sentences, grammar, usage notes, synonyms and more.

  8. 1. a. a condition of constant change or alternation, as a natural process; mutability. the vicissitude of the sea. b. regular succession or alternation, as of night and day. 2. [pl.] unpredictable changes or variations that keep occurring in life, fortune, etc.; shifting circumstances; ups and downs. 3.

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