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  1. Dec 6, 2019 · Abstract. Surgical procedures represent a serious hemostatic challenge for patients with von Willebrand disease (VWD), and careful perioperative management is required to minimize bleeding risk. Risk stratification includes not only the nature of the surgery to be performed but the baseline plasma von Willebrand factor (VWF) levels, bleeding ...

    • James S. O’Donnell, Michelle Lavin
    • 2019
  2. Jan 4, 2022 · The management of patients with VWD who are undergoing surgeries is crucial to prevent bleeding complications. We systematically summarized the evidence on the management of patients with VWD who are undergoing major and minor surgeries to support the development of practice guidelines.

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  4. Jun 4, 2020 · This review provides an overview of the current evidence for the surgical management of patients with VWD and, summarises the optimal treatment approach during the perioperative period, and highlights key unanswered questions and the research needed to address the evidence gaps.

    • Wolfgang Miesbach
    • 2020
  5. Dec 3, 2015 · Objectives: von Willebrand disease (VWD) is the most common hereditary bleeding disorder. This study reviews the management of perioperative anticoagulation in patients with VWD undergoing surgical procedures.

    • Mario Von Depka, Carsten Detering, Stefanie Döpke, Mahnaz Ekhlasi-Hundrieser
    • 2015
  6. Treatment guidelines recommend the use of pure von Willebrand factor or von Willebrand factor/factor VIII (vWF/FVIII) concentrate in patients with type 2 or type 3 vWD undergoing surgery, in patients with type 1 vWD undergoing surgery who are unresponsive, and in patients for whom desmopressin acetate is contraindicated.

    • Bulent Zulfikar, Basak Koc, Gulsum Ak, Fatih Dikici, İhsan Karaman, Ata Can Atalar, Fikret Bezgal
    • 2016
  7. Sep 13, 2016 · Von Willebrand disease – the ‘Dos’ and ‘Don'ts’ in surgery. Wolfgang Miesbach, Erik Berntorp. First published: 13 September 2016. https://doi.org/10.1111/ejh.12809. Citations: 27. Read the full text. PDF. Tools. Share. Abstract. Von Willebrand disease (VWD) is the most common genetic bleeding disorder.

  8. Mar 1, 2008 · Von Willebrand disease (vWD), a hemorrhagic disorder mimicking a defect in platelet function, is the most commonly inherited coagulopathy, resulting in a deficiency that may prolong bleeding time and increase risk for major bleeding complications during surgery.

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  2. Visit the VONVENDI® [von Willebrand factor (Recombinant)] website for patient resources.

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