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Diabetes Insipidus (DI) and Syndrome of Inappropriate Antidiuretic Hormone (SIADH) Secretion are both disorders of water metabolism. The posterior pituitary gland secretes anti-diuretic hormone (ADH). ADH is responsible for regulation of water balance and serum osmolality.
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Jan 5, 2021 · Diabetes insipidus is a relatively rare endocrine disorder that presents with hypotonic polyuria and polydipsia. It can result from either inadequate secretion of AVP (CDI), lack of renal response to AVP (NDI), or excessive fluid intake (PP).
- Gagan Priya, Sanjay Kalra, Arundhati Dasgupta, Emmy Grewal
- 10.7759/cureus.12498
- 2021
- Cureus. 2021 Jan; 13(1): e12498.
Nov 28, 2022 · Diabetes insipidus (DI) is a disorder characterized by excretion of large volumes of hypotonic urine. The underlying cause is either a deficiency of the hormone arginine vasopressin (AVP) in the pituitary gland/hypothalamus (central DI), or resistance to the actions of AVP in the kidneys (nephrogenic DI).
- Sriram Gubbi, Fady Hannah-Shmouni, Christian A Koch, Joseph G Verbalis
- 2022/11/28
- 2019
Feb 23, 2021 · The two main classifications of DI are central diabetes insipidus (CDI), characterized by a deficiency of the posterior pituitary gland to release ADH, and nephrogenic diabetes insipidus (NDI), characterized by the terminal distal convoluted tubule and collecting duct resistance to ADH.
- Cody M Mutter, Trevor Smith, Olivia Menze, Mariah Zakharia, Hoang Nguyen
- 10.7759/cureus.13523
- 2021
- Cureus. 2021 Feb; 13(2): e13523.
- Overview
- Symptoms
- Causes
- Risk Factors
- Complications
- Clinical Trials
Diabetes insipidus (die-uh-BEE-teze in-SIP-uh-dus) is an uncommon problem that causes the fluids in the body to become out of balance. That prompts the body to make large amounts of urine. It also causes a feeling of being very thirsty even after having something to drink. Diabetes insipidus also is called arginine vasopressin deficiency and argini...
Symptoms of diabetes insipidus in adults include: 1. Being very thirsty, often with a preference for cold water. 2. Making large amounts of pale urine. 3. Getting up to urinate and drink water often during the night. Adults typically urinate an average of 1 to 3 quarts (about 1 to 3 liters) a day. People who have diabetes insipidus and who drink a ...
Diabetes insipidus happens when the body can't balance its fluid levels in a healthy way. Fluid in the blood is filtered through the kidneys to remove waste. Afterward, most of that fluid is returned to the bloodstream. The waste and a small amount of fluid leave the kidneys as urine. Urine leaves the body after it's temporarily stored in the bladd...
Anyone can get diabetes insipidus. But those at higher risk include people who: 1. Have a family history of the disorder. 2. Take certain medicines, such as diuretics, that could lead to kidney problems. 3. Have high levels of calcium or low levels of potassium in their blood. 4. Have had a serious head injury or brain surgery.
Dehydration
Diabetes insipidus may lead to dehydration. That happens when the body loses too much fluid. Dehydration can cause: 1. Dry mouth. 2. Thirst. 3. Extreme tiredness. 4. Dizziness. 5. Lightheadedness. 6. Fainting. 7. Nausea.
Electrolyte imbalance
Diabetes insipidus can change the levels of minerals in the blood that maintain the body's balance of fluids. Those minerals, called electrolytes, include sodium and potassium. Symptoms of an electrolyte imbalance may include: 1. Weakness. 2. Nausea. 3. Vomiting. 4. Loss of appetite. 5. Confusion.
Explore Mayo Clinic studiestesting new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition.
Diabetes insipidus is a rare but treatable condition in which your body produces too much urine (pee) and isn’t able to properly retain water. Diabetes insipidus can be chronic (life-long) or temporary and mild or severe depending on the cause.
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Defines diabetes insipidus and reviews the mechanics of normal fluid regulation. Discusses the different forms of the condition and the tests used to diagnose it. Lists organizations that can provide additional information.
