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  1. 1. a. : the quality or state of being changeable : mutability. b. : natural change or mutation visible in nature or in human affairs. 2. a. : a favorable or unfavorable event or situation that occurs by chance : a fluctuation of state or condition. the vicissitudes of daily life.

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  3. VICISSITUDES definition: 1. changes that happen at different times during the life or development of someone or something…. Learn more.

  4. noun. a variation in circumstances or fortune at different times in your life or in the development of something. “the project was subject to the usual vicissitudes of exploratory research” see more. noun. mutability in life or nature (especially successive alternation from one condition to another) see more. Cite this entry. Style: MLA.

  5. noun. a change or variation occurring in the course of something. interchange or alternation, as of states or things. vicissitudes, successive, alternating, or changing phases or conditions, as of life or fortune; ups and downs: They remained friends through the vicissitudes of 40 years.

  6. VICISSITUDES meaning: 1. changes that happen at different times during the life or development of someone or something…. Learn more.

  7. You use vicissitudes to refer to changes, especially unpleasant ones, that happen to someone or something at different times in their life or development.

  8. 1. a. a condition of constant change or alternation, as a natural process; mutability. the vicissitude of the sea. b. regular succession or alternation, as of night and day. 2. [pl.] unpredictable changes or variations that keep occurring in life, fortune, etc.; shifting circumstances; ups and downs. 3.

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