Search results
Jan 1, 1996 · Muscular dystrophies are a group of inherited disorders characterized by progressive muscle wasting and weakness, in which muscle histopathology shows certain distinctive features (muscle fiber...
Searches related to muscular dystrophy research paper sample pdf
Jun 26, 2023 · Duchenne muscular dystrophy (DMD) is a severe, progressive, and ultimately fatal disease of skeletal muscle wasting, respiratory insufficiency, and cardiomyopathy. The identification of the dystrophin gene as central to DMD pathogenesis has led to the understanding of the muscle membrane and the proteins involved in membrane stability as the ...
Nov 12, 2020 · Muscular exercise can be recommended to improve endurance during walking in most patients with muscular dystrophy. It is important, however, that the patient understands that the benefits might be only marginal.
- Silvia Gianola, Greta Castellini, Valentina Pecoraro, Marco Monticone, Giuseppe Banfi, Lorenzo Moja
- 10.3389/fneur.2020.00958
- 2020
- Front Neurol. 2020; 11: 958.
- Abstract
- Clinical and preclinical therapeutic strategies for DMD
- Prospects
- Declarations
Duchenne muscular dystrophy (DMD) is a severe, progressive, muscle-wasting disease, characterized by progressive dete-rioration of skeletal muscle that causes rapid loss of mobility. The failure in respiratory and cardiac muscles is the underly-ing cause of premature death in most patients with DMD. Mutations in the gene encoding dystrophin result ...
Numerous therapies for DMD are currently under develop-ment, which in general can be divided into two categories: restoring dystrophin expression (Table 1) and alleviating adverse symptoms caused by abnormal dystrophin expres-sion (Table 2). Treatments cannot reverse muscle loss and dysfunction of DMD patients, so it is important to treat and del...
Currently, the expression of the DMD gene is the main basis for the diagnosis of DMD. The absence of dystrophin causes abnormal function of the relevant complexes, which triggers a series of subsequent pathological processes. The involvement of multiple organs such as bones, myocar-dium, and lungs are fatal for patients. Especially fibrosis of the ...
Conflicts of interest All authors have no conflict of interest to disclose.
Feb 18, 2021 · Duchenne muscular dystrophy (DMD) is a severe, progressive, muscle-wasting disease. The earliest symptoms are difficulties with climbing stairs, a waddling gate and frequent falls; patients...
- Dongsheng Duan, Nathalie Goemans, Shin'ichi Takeda, Eugenio Mercuri, Annemieke Aartsma-Rus
- 2021
The muscular dystrophies (MDs) are a heterogeneous group of inherited disorders characterized by progressive weakness and degeneration of skeletal muscles (Table). They have traditionally been classified by clinical presentation, mode of inheritance, age of onset, and overall progression.
People also ask
What are muscular dystrophies?
What is the literature on Muscular dystrophies?
Are dystrophic mice a model for Duchenne muscular dystrophy?
Are physical therapists more likely to see a patient with muscular dystrophy?
Jan 19, 2018 · Background and purpose: Duchenne muscular dystrophy (DMD) is a lethal progressive pediatric muscle disorder and genetically inherited as an X-linked disease that caused by mutations in the...
