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    • Upregulated by HlyA

      • In the present study, granulocyte-macrophage colony-stimulating factor (GM-CSF) secreted by renal epithelial cells was upregulated by HlyA in vitro and in vivo, which induced M1 macrophage accumulation in kidney, and ADAM10 was found involved in HlyA-induced GM-CSF.
      pubmed.ncbi.nlm.nih.gov › 31719643

      Alpha-hemolysin of uropathogenic Escherichia coli induces GM ...

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  3. www.nature.com › articles › s41385/019/0225-6Alpha-hemolysin of uropathogenic Escherichia coli induces GM ...

    Nov 12, 2019 · In the present study, granulocyte-macrophage colony-stimulating factor (GM-CSF) secreted by renal epithelial cells was upregulated by HlyA in vitro and in vivo, which induced M1 macrophage...

  4. pubmed.ncbi.nlm.nih.gov › 31719643Alpha-hemolysin of uropathogenic Escherichia coli induces GM ...

    In the present study, granulocyte-macrophage colony-stimulating factor (GM-CSF) secreted by renal epithelial cells was upregulated by HlyA in vitro and in vivo, which induced M1 macrophage accumulation in kidney, and ADAM10 was found involved in HlyA-induced GM-CSF. Macrophage elimination or GM-CSF neutralization protected against acute kidney ...

    • Changying Wang, Qianqian Li, Junqiang Lv, Xuan Sun, Yang Cao, Kaiyuan Yu, Chunhui Miao, Zhi-Song Zha...
    • 2020

  5. www.ncbi.nlm.nih.gov › pmc › articlesGM-CSF: A Double-Edged Sword in Cancer Immunotherapy

    Jul 5, 2022 · GM-CSF promotes anti-tumor immune responses by activating monocytes/macrophages and enhancing DC differentiation . GM-CSF induces an inflammatory profile in human monocytes, which includes an upregulated expression of HLA-DR and CD86 molecules and increased production of TNF-α and IL-1β .

  6. www.researchgate.net › figure › HlyA-promotes-GM-CSFHlyA promotes GM-CSF secretion in renal epithelial cells ...

    HlyA promotes GM-CSF secretion in renal epithelial cells during kidney infections. a, b GM-CSF mRNA (a) or secreted GM-CSF (b) in 786-O cells treated with CFT073, ΔhlyA or ΔhlyA...

  7. www.ncbi.nlm.nih.gov › pmc › articlesGM-CSF: A Promising Target in Inflammation and Autoimmunity

    Oct 29, 2020 · While GM-CSF appears to be dispensable for steady state myeloid cell development in vivo, 24 GM-CSF directly regulates the differentiation of liver-derived fetal monocytes into immature alveolar macrophages during embryonic development 25 and also promotes the development of functional alveolar macrophages via PU.1. 25, 26 GM-CSF gene-deficient ...

    • Kevin M C Lee, Adrian A Achuthan, John A Hamilton
    • 2020

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  9. www.ncbi.nlm.nih.gov › pmc › articlesGM-CSF: Orchestrating the Pulmonary Response to Infection

    Jan 17, 2022 · Granulocyte-macrophage colony-stimulating factor (GM-CSF) is an immune-modulating cytokine that plays a critical role in maintaining the alveolar epithelium and pulmonary immune system under homeostatic and pathologic conditions, including infection ( Rosler and Herold, 2016; Lang et al., 2020 ).

  10. www.semanticscholar.org › paper › MatrixMatrix Metalloproteinase-2, Matrix Metalloproteinase-9, and ...

    G granulocyte-macrophage colony-stimulating factor (GM-CSF) secreted by renal epithelial cells was upregulated by HlyA in vitro and in vivo, which induced M1 macrophage accumulation in kidney, and ADAM10 was found involved in HlA-induced GM-CSf.

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