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Feb 23, 2022 · The analysis showed that in some settings the bias on relative survival estimates reached 4.0–5.7 percentage points and the authors concluded that lead time bias should not be neglected when interpreting trends in breast cancer survival or differences between population groups in settings where there could be differences in screening ...
Dec 25, 2023 · Lead-time bias occurs when an asymptomatic breast cancer is detected by routine screening mammography at an earlier time point in its natural history than when it would have been detected clinically. For example, a patient may survive for 15 years after a screen-detected diagnosis compared with surviving only 10 years after a clinically ...
Feb 1, 2017 · In summary, the possibility of lead-time bias should not be neglected when interpreting trends in breast cancer survival or differences between groups or countries. It is, however, not likely to have a great impact on survival estimates. Funding
- Therese M.-L. Andersson, Mark J. Rutherford, Keith Humphreys
- 2017
approach based on Swedish breast cancer data [22]. e analysis showed that in some settings the bias on rela-tive survival estimates reached 4.0–5.7 percentage points and the authors concluded that lead time bias should not be neglected when interpreting trends in breast can-cer survival or dierences between population groups
through any link between tumour size and survival. We explain how this has a bearing on how observable breast cancer-specific survival curves should be interpreted. We also propose an approach for correcting survival comparisons for the length bias. Keywords Lead time, length bias, breast cancer, screening effect, counterfactual survival 1 ...
Comparisons of survival times between screen-detected and symptomatically detected breast cancer cases are subject to lead time and length biases. Whilst the existence of these biases is well known, correction procedures for these are not always clear, as are not the interpretation of these biases. …
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Should lead time bias be neglected when interpreting trends in breast cancer survival?
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Feb 23, 2022 · To isolate the lead time bias of screening, we assumed that screening does not affect the actual time of death. ... not be neglected when interpreting trends in breast can- ... on breast cancer ...
