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  1. The clinical approach to sleep and circadian disorders in dementia begins with assessing for and treating primary sleep disorders, then managing co-morbid conditions and medications that may be negatively affecting sleep, then behavioral interventions, and then pharmacological treatments.

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  3. We searched up to February 2020 for well-designed trials that compared any medicine used for treating sleep problems in people with dementia with a fake medicine (placebo). We consulted a panel of carers to help us identify the most important outcomes to look for in the trials.

  4. Nov 15, 2020 · Drugs that have been used to manage sleep disorders in people with dementia include atypical antipsychotics, benzodiazepines, other GABAergic drugs (such as zolpidem, zopiclone, and zaleplon), melatonin, sedating antidepressants, and antihistamines.

    • Jenny McCleery, Daniel A. Cohen, Ann L Sharpley
    • 10.1002/14651858.CD009178.pub4
    • 2016
    • 2020
  5. The main drugs used to treat RBD are melatonin and clonazepam. Melatonin tends to be prescribed more for people with dementia, as clonazepam may worsen other symptoms of dementia and leave the person feeling drowsy during the day.

    • Common Sleep Changes
    • Contributing Medical Factors
    • Non-Drug Treatments For Sleep Changes
    • Medications For Sleep Changes

    Many people with Alzheimer’s experience changes in their sleep patterns. Scientists do not completely understand why this happens. As with changes in memory and behavior, sleep changes somehow result from the impact of Alzheimer’s on the brain. Many older adults without dementia also notice changes in their sleep, but these disturbances occur more ...

    A person experiencing sleep disturbances should have a thorough medical exam to identify any treatable illnesses that may be contributing to the problem. Examples of conditions that can make sleep problems worse include: 1. Depression 2. Restless legs syndrome, a disorder in which unpleasant “crawling” or “tingling” sensations in the legs cause an ...

    Non-drug treatments aim to improve sleep routine and the sleeping environment and reduce daytime napping. Non-drug coping strategies should always be tried before medications, since some sleep medications can cause serious side effects. To create an inviting sleeping environment and promote rest for a person with Alzheimer’s: 1. Maintain regular ti...

    The type of medication prescribed by a doctor is often influenced by behaviors that may accompany the sleep changes. The decision to use an antipsychotic drug should be considered with extreme caution. Research has shown that these drugs are associated with an increased risk of stroke and death in older adults with dementia. The U.S. Food and Drug ...

  6. Nov 15, 2020 · Objectives: To assess the effects, including common adverse effects, of any drug treatment versus placebo for sleep disorders in people with dementia.

  7. Nov 16, 2016 · In particular, we found no RCTs of many drugs that are widely prescribed for sleep problems in dementia, including the benzodiazepine and non-benzodiazepine hypnotics, although there is considerable uncertainty about the balance of benefits and risks associated with these common treatments.

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