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  1. a. : a favorable or unfavorable event or situation that occurs by chance : a fluctuation of state or condition. the vicissitudes of daily life. b. : a difficulty or hardship attendant on a way of life, a career, or a course of action and usually beyond one's control. c. : alternating change : succession.

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  3. Losing a pet, crashing the car, being called in for jury duty: these are examples of vicissitudes — chapters in one's life that one would rather avoid but must get through. Some lives have more vicissitudes than others, to be sure, but no life is without events that test and challenge us.

  4. a change or variation occurring in the course of something. interchange or alternation, as of states or things. vicissitudes, successive, alternating, or changing phases or conditions, as of life or fortune; ups and downs: They remained friends through the vicissitudes of 40 years.

  5. As already observed, the vicissitudes of general economic equilibrium theory are a good example of the spread of the mathematical modeling approach.

  6. May 31, 2017 · 'Vicissitude' in a sentence: Getting to bed and waking at the same time each day helps buffer me from the vicissitudes of life and my illness.

  7. A condition of constant change or alternation, as a natural process; mutability. The vicissitude of the sea. Regular succession or alternation, as of night and day. Unpredictable changes or variations that keep occurring in life, fortune, etc.; shifting circumstances; ups and downs.

  8. changes that happen at different times during the life or development of someone or something, especially those that result in conditions being worse: Losing your job is just one of the vicissitudes of life. SMART Vocabulary: related words and phrases.

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