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Amantadine (brand names Gocovri, Symadine, and Symmetrel [1] [16]) is the organic compound 1-adamantylamine or 1-aminoadamantane, which consists of an adamantane backbone with an amino group substituted at one of the four tertiary carbons. [17] Rimantadine is a closely related adamantane derivative with similar biological properties; [18] both ...
- C₁₀H₁₇N
- AU: B3
- Minimal (mostly to acetyl metabolites)
- Gocovri, Symadine, Symmetrel, others
Descriptions. Amantadine is an antidyskinetic medicine. It is used to treat Parkinson's disease (sometimes called "paralysis agitans" or "shaking palsy") and its symptoms, including dyskinesia (sudden uncontrolled movements). It may be given alone or in combination with other medicines (eg, levodopa) for Parkinson's disease.
- Overview
- Why is this medication prescribed?
- How should this medicine be used?
- Other uses for this medicine
- What special precautions should I follow?
- What special dietary instructions should I follow?
- What should I do if I forget a dose?
- What side effects can this medication cause?
- What should I know about storage and disposal of this medication?
- In case of emergency/overdose
pronounced as (a man' ta deen)
•Why is this medication prescribed?
•How should this medicine be used?
•Other uses for this medicine
•What special precautions should I follow?
•What special dietary instructions should I follow?
Amantadine is used to treat the symptoms of Parkinson's disease (PD; a disorder of the nervous system that causes difficulties with movement, muscle control, and balance) and other similar conditions. It is also used to control movement problems that are a side effect of certain medications used to treat Parkinson's disease. Amantadine extended-rel...
Amantadine comes as a capsule, extended-release capsule (Gocovri), tablet, extended-release tablet (Osmolex), and liquid to take by mouth. The capsules, tablets, and liquid medications are usually taken once or twice a day. The extended-release capsules are usually taken once a day at bedtime. The extended-release tablets are usually taken once a day in the morning. Take amantadine at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take amantadine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Swallow the extended-release capsules and extended-release tablets whole; do not split, chew, or crush them. If you have difficulty swallowing the extended-release capsule, you may open the capsule and sprinkle the entire contents on a teaspoonful of soft food, like applesauce. Eat the mixture right away and swallow without chewing.
If you are taking amantadine for Parkinson's disease, your doctor may start you on a low dose of amantadine and gradually increase your dose.
Do not stop taking amantadine without talking to your doctor. If you suddenly stop taking amantadine, you may experience fever, confusion, changes in mental state, or severe muscle stiffness. Your doctor will probably decrease your dose gradually.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Before taking amantadine,
tell your doctor and pharmacist if you are allergic to amantadine, any other medications, or any of the ingredients in amantadine capsules, extended-release capsules, tablets, extended-release tablets, or liquid. Ask your pharmacist for a list of the ingredients. Tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take while taking amantadine. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. The following nonprescription products may interact with amantadine: allergy medications (diphenhydramine, loratadine, fexofenadine, chlorpheniramine or cetirizine), sleep medications, motion sickness medications, sodium bicarbonate (Alka-Seltzer, in Zegerid). Be sure to let your doctor and pharmacist know that you are taking these medications before you start taking amantadine. Do not start any of these medications while taking amantadine without discussing with your healthcare provider. tell your doctor if you have kidney disease. Your doctor may tell you not to take amantadine. tell your doctor if you drink or have ever drunk large amounts of alcohol, use or have ever used street drugs, or have overused prescription medications or if you have or have ever had depression, unusual changes in behavior or mood, mental illness, or thoughts about or attempted suicide; epilepsy or any other type of seizures; a sleep disorder; urinary tract infections; glaucoma (a condition in which increased pressure in the eye can lead to gradual loss of vision); eczema (atopic dermatitis; a skin disease that causes the skin to be dry and itchy and to sometimes develop red, scaly rashes); heart failure; swelling of the hands, feet, ankles, or lower legs; low blood pressure; or liver disease. tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking amantadine, call your doctor immediately. Amantadine may cause harm to the fetus. you should know that amantadine may make you drowsy or cause blurred vision. Do not drive a car, operate machinery, or participate in potentially dangerous activities until you know how this medication affects you. you should know that amantadine may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking amantadine or if your dose has been increased. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up. do not have any vaccinations without talking to your doctor. you should know that some people taking amantadine and other similar medications used to treat Parkinson's disease have developed gambling problems or have had other intense urges or behaviors that were compulsive or unusual for them, such as increased sexual urges, binge eating, or uncontrolled spending. Call your doctor if you have an urge to gamble that is difficult to control, you have intense urges, or you are unable to control your behavior. Tell your family members about this risk so that they can call the doctor even if you do not realize that your gambling or any other intense urges or unusual behaviors have become a problem.
Unless your doctor tells you otherwise, continue your normal diet.
If you are taking the capsules, tablets, or liquid, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
If you are taking the extended-release capsules or the extended-release tablets, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one. If you have forgotten to take the extended-release capsules or extended-release tablets for several days, call your doctor.
Amantadine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
dry mouth constipation nausea vomiting decreased appetite difficulty falling asleep or staying asleep abnormal dreams headache confusion drowsiness tiredness uncontrollable tightening of muscles, change from normal walking, and falls lace-like purple pattern on skin
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:
hallucinations (seeing things or hearing voices that do not exist) believing things that are not true not trusting others or feeling that others want to hurt you depression anxiety suicidal (thinking about harming or killing oneself or planning or trying to do so) lack of interest, enthusiasm, or concern dizziness, lightheadedness, fainting, or blurred vision swelling of the hands, feet, ankles, or lower legs difficulty urinating shortness of breath Amantadine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org
Symptoms of overdose may include the following:
irregular or fast heartbeat difficulty breathing decreased urination swelling of the hands, feet, ankles or lower legs stiff or rigid arms or legs uncontrollable movements or shaking of a part of the body problems with coordination confusion feeling like you are looking at yourself as an outside observer fear, irritability, or aggressive behavior seeing things or hearing voices that do not exist lack of energy
Apr 24, 2023 · Amantadine is an antiviral agent with mild antiparkinsonian activity. Amantadine was used in the early 2000s for Influenza A treatment. However, high levels of resistance have emerged recently, initially from Asia and now in North America. As of 2011, the CDC does not recommend treatment or prophylaxis of influenza A due to the high levels of resistance. Amantadine is now used mostly for ...
- Carol Chang, Kamleshun Ramphul
- 2023/04/24
Aug 15, 2023 · Common amantadine side effects may include: dizziness, falls; dry mouth; swelling in your legs or feet; nausea, constipation; or. sleep problems ( insomnia ). This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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- Consultant Pharmacist
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Amantadine, sold under the brand name Gocovri among others, is a medication used to treat dyskinesia associated with parkinsonism and influenza caused by type A influenzavirus, though its use for the latter is no longer recommended because of widespread drug resistance. It acts as a nicotinic antagonist, dopamine agonist, and noncompetitive NMDA antagonist. The antiviral mechanism of action is ...
Apr 19, 2018 · Amantadine oral capsule is available as a brand-name drug and a generic drug. Brand name: Gocovri. Amantadine comes in five forms: oral immediate-release capsule, extended-release capsule ...
